The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference
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The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference. / Graff, J; Fugleberg, S; Brahm, J; Fogh-Andersen, N.
I: Clinical physiology (Oxford, England), Bind 16, Nr. 3, 05.1996, s. 291-300.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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T1 - The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference
AU - Graff, J
AU - Fugleberg, S
AU - Brahm, J
AU - Fogh-Andersen, N
PY - 1996/5
Y1 - 1996/5
N2 - Six kinetic models of transperitoneal phosphate transport were formulated and validated on the basis of experimental results obtained from 22 non-diabetic patients undergoing peritoneal dialysis. The models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective, and lymphatic convective phosphate transport. Calculations allowed for a 20% protein binding of phosphate. The validation procedure demonstrated that only diffusive and non-lymphatic convective phosphate transport mechanisms were identifiable. A lymphatic convective phosphate transport mechanism was not identifiable. Furthermore, it was demonstrated that the electrochemical gradient between plasma water and dialysate favours the diffusive phosphate transport, and both electric and chemical potentials must be taken into account in calculations of the transperitoneal phosphate transport.
AB - Six kinetic models of transperitoneal phosphate transport were formulated and validated on the basis of experimental results obtained from 22 non-diabetic patients undergoing peritoneal dialysis. The models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective, and lymphatic convective phosphate transport. Calculations allowed for a 20% protein binding of phosphate. The validation procedure demonstrated that only diffusive and non-lymphatic convective phosphate transport mechanisms were identifiable. A lymphatic convective phosphate transport mechanism was not identifiable. Furthermore, it was demonstrated that the electrochemical gradient between plasma water and dialysate favours the diffusive phosphate transport, and both electric and chemical potentials must be taken into account in calculations of the transperitoneal phosphate transport.
KW - Adult
KW - Diffusion
KW - Electrophysiology
KW - Female
KW - Humans
KW - Lymphatic System
KW - Male
KW - Models, Biological
KW - Peritoneal Dialysis
KW - Phosphates
KW - Protein Binding
M3 - Journal article
C2 - 8736715
VL - 16
SP - 291
EP - 300
JO - Clinical Physiology
JF - Clinical Physiology
SN - 0144-5979
IS - 3
ER -
ID: 94517434