The T-peak–T-end Interval as a Marker of Repolarization Abnormality: A Comparison with the QT Interval for Five Different Drugs
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The T-peak–T-end Interval as a Marker of Repolarization Abnormality : A Comparison with the QT Interval for Five Different Drugs. / Bhuiyan, Tanveer A.; Graff, Claus; Kanters, Jørgen K.; Nielsen, Jimmi; Melgaard, Jacob; Matz, Jørgen; Toft, Egon; Struijk, Johannes J.
I: Clinical Drug Investigation, Bind 35, Nr. 11, 11.2015, s. 717-724.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The T-peak–T-end Interval as a Marker of Repolarization Abnormality
T2 - A Comparison with the QT Interval for Five Different Drugs
AU - Bhuiyan, Tanveer A.
AU - Graff, Claus
AU - Kanters, Jørgen K.
AU - Nielsen, Jimmi
AU - Melgaard, Jacob
AU - Matz, Jørgen
AU - Toft, Egon
AU - Struijk, Johannes J.
PY - 2015/11
Y1 - 2015/11
N2 - BACKGROUND AND OBJECTIVE: The T-peak to T-end (TpTe) interval has been suggested as an index of transmural dispersion and as a marker of drug-induced abnormal repolarization. In this study, we investigate the relation between TpTe and the QT interval.METHODS: Electrocardiograms (ECGs) from five different drugs (sotalol, sertindole, moxifloxacin, nalmefene, and Lu 38-135) and from a placebo group were analyzed. Semi-automatic measurements of T-peak, T-end, and QRS onset were obtained. The TpTe/QT ratio was calculated to investigate the proportional relationship of QT and TpTe.RESULTS: Although a significant increase of both TpTe and QT from baseline is apparent with QT-prolonging drugs, the TpTe/QT ratio remained the same at baseline and after drug administration, thus indicating that prolongation of TpTe is just a fractional part of total QT prolongation. In the presence of notched or flattened T-waves, the uncertainty associated with measurement of the TpTe interval increases. The errors in TpTe for individual subjects may be substantial, thus complicating the use of TpTe for follow-up of individuals.CONCLUSIONS: The duration of the QT interval and TpTe are closely related. Drugs appear to prolong the TpTe interval as a predictable fraction of the total QT prolongation.
AB - BACKGROUND AND OBJECTIVE: The T-peak to T-end (TpTe) interval has been suggested as an index of transmural dispersion and as a marker of drug-induced abnormal repolarization. In this study, we investigate the relation between TpTe and the QT interval.METHODS: Electrocardiograms (ECGs) from five different drugs (sotalol, sertindole, moxifloxacin, nalmefene, and Lu 38-135) and from a placebo group were analyzed. Semi-automatic measurements of T-peak, T-end, and QRS onset were obtained. The TpTe/QT ratio was calculated to investigate the proportional relationship of QT and TpTe.RESULTS: Although a significant increase of both TpTe and QT from baseline is apparent with QT-prolonging drugs, the TpTe/QT ratio remained the same at baseline and after drug administration, thus indicating that prolongation of TpTe is just a fractional part of total QT prolongation. In the presence of notched or flattened T-waves, the uncertainty associated with measurement of the TpTe interval increases. The errors in TpTe for individual subjects may be substantial, thus complicating the use of TpTe for follow-up of individuals.CONCLUSIONS: The duration of the QT interval and TpTe are closely related. Drugs appear to prolong the TpTe interval as a predictable fraction of the total QT prolongation.
U2 - 10.1007/s40261-015-0328-0
DO - 10.1007/s40261-015-0328-0
M3 - Journal article
C2 - 26410545
VL - 35
SP - 717
EP - 724
JO - Clinical Drug Investigation
JF - Clinical Drug Investigation
SN - 1173-2563
IS - 11
ER -
ID: 160775144