The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Bone Oncology |
Vol/bind | 5 |
Udgave nummer | 3 |
Sider (fra-til) | 100-103 |
Antal sider | 4 |
ISSN | 2212-1366 |
DOI | |
Status | Udgivet - sep. 2016 |
ID: 174632985