The prevalence of EGFR mutations in non-small cell lung cancer in an unselected Caucasian population
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The prevalence of EGFR mutations in non-small cell lung cancer in an unselected Caucasian population. / Skov, Birgit G; Høgdall, Estrid; Clementsen, Paul; Krasnik, Mark; Larsen, Klaus Richter; Sørensen, Jens Benn; Skov, Torsten; Mellemgaard, Anders.
I: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Bind 123, Nr. 2, 02.2015, s. 108-115.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The prevalence of EGFR mutations in non-small cell lung cancer in an unselected Caucasian population
AU - Skov, Birgit G
AU - Høgdall, Estrid
AU - Clementsen, Paul
AU - Krasnik, Mark
AU - Larsen, Klaus Richter
AU - Sørensen, Jens Benn
AU - Skov, Torsten
AU - Mellemgaard, Anders
N1 - © 2014 APMIS. Published by John Wiley & Sons Ltd.
PY - 2015/2
Y1 - 2015/2
N2 - EGFR mutation frequencies in unselected Caucasian populations are unknown. This study assesses the prevalence of EGFR mutations in an unselected population-based cohort, and the correlation between mutation and gender, age, ethnicity, smoking habits, and pathological data. NSCLC patients diagnosed in a well-defined Danish population were included. The type of the diagnostic material, and data on smoking were registered. The mutation analyses were investigated by Therascreen EGFR RGQ-PCR Kit or Sanger sequencing. A total of 658 men and 598 women were included. 6.2% were never smokers, 38.9% were ex-smokers, and 54.9% were current smokers. One thousand one hundred and sixty-one (92.4%) patients had sufficient material for mutation analysis. Cytological material was used for 38% of the mutation analyses. 5.4% had mutation in the EGFR gene (4.3% men/6.7% women). 87% were activating mutations. 8.0% of adenocarcinomas, and 1.9% of squamous cell carcinomas were mutated. 29.4%, 4.4% and 2.9% of never, ex- and current smokers were mutated (p < 0.001). No difference in mutation rate was observed between patients with cytology only, histology only or both cytology and histology available. 5.4% of the patients had EGFR mutation. Adenocarcinomas were mutated more often (8.0%) than squamous cell carcinomas (1.9%). Mutations were found in never smokers as well as in former and current smokers. No difference in gender and age regarding mutation status was observed. EGFR mutations analysis was possible in almost all patients with no difference between cytology and histology specimens.
AB - EGFR mutation frequencies in unselected Caucasian populations are unknown. This study assesses the prevalence of EGFR mutations in an unselected population-based cohort, and the correlation between mutation and gender, age, ethnicity, smoking habits, and pathological data. NSCLC patients diagnosed in a well-defined Danish population were included. The type of the diagnostic material, and data on smoking were registered. The mutation analyses were investigated by Therascreen EGFR RGQ-PCR Kit or Sanger sequencing. A total of 658 men and 598 women were included. 6.2% were never smokers, 38.9% were ex-smokers, and 54.9% were current smokers. One thousand one hundred and sixty-one (92.4%) patients had sufficient material for mutation analysis. Cytological material was used for 38% of the mutation analyses. 5.4% had mutation in the EGFR gene (4.3% men/6.7% women). 87% were activating mutations. 8.0% of adenocarcinomas, and 1.9% of squamous cell carcinomas were mutated. 29.4%, 4.4% and 2.9% of never, ex- and current smokers were mutated (p < 0.001). No difference in mutation rate was observed between patients with cytology only, histology only or both cytology and histology available. 5.4% of the patients had EGFR mutation. Adenocarcinomas were mutated more often (8.0%) than squamous cell carcinomas (1.9%). Mutations were found in never smokers as well as in former and current smokers. No difference in gender and age regarding mutation status was observed. EGFR mutations analysis was possible in almost all patients with no difference between cytology and histology specimens.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Non-Small-Cell Lung
KW - DNA Mutational Analysis
KW - European Continental Ancestry Group
KW - Female
KW - Humans
KW - Lung Neoplasms
KW - Male
KW - Middle Aged
KW - Mutation
KW - Mutation Rate
KW - Neoplasm Metastasis
KW - Prospective Studies
KW - Receptor, Epidermal Growth Factor
KW - Smoking
KW - Young Adult
U2 - 10.1111/apm.12328
DO - 10.1111/apm.12328
M3 - Journal article
C2 - 25421919
VL - 123
SP - 108
EP - 115
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 2
ER -
ID: 156088019