The pathways of oxygen in brain. II. Competitions for cytochrome c oxidase and NOS are keys to flow-metabolism coupling
Publikation: Konferencebidrag › Paper › Forskning › fagfællebedømt
It has been well-known for many years that cerebral oxygen consumption remains constant during moderate changes of blood flow, as measured during hypo- or hypercapnia or indomethacin administration. Current models of flow-metabolism coupling link blood-brain transfer of oxygen to oxygen metabolism in mitochondria. The resulting quantitative relations between flow and metabolism reveal that a close link between diffusion and metabolism prevents the enzyme from maintaining a constant oxygen consumption when blood flow changes, unless the enzyme's affinity towards oxygen is adjusted commensurately.
Originalsprog | Engelsk |
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Publikationsdato | 2005 |
Antal sider | 6 |
Status | Udgivet - 2005 |
Eksternt udgivet | Ja |
Begivenhed | The pathways of oxygen in brain. II. Competitions for cytochrome c oxidase and NOS are keys to flow-metabolism coupling - Varighed: 29 nov. 2010 → … |
Konference
Konference | The pathways of oxygen in brain. II. Competitions for cytochrome c oxidase and NOS are keys to flow-metabolism coupling |
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Periode | 29/11/2010 → … |
Bibliografisk note
Volume: 566
Sider: 277-83
ID: 14943549