The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood. / Schnurr, Theresia M.; Morgen, Camilla S.; Borisevich, Dmitrii; Beaumont, Robin N.; Engelbrechtsen, Line; Ängquist, Lars; Have, Christian T.; Freathy, Rachel M.; Smith, George Davey; Nohr, Ellen A.; Hansen, Torben; Sørensen, Thorkild I.A.
I: Scientific Reports, Bind 10, Nr. 1, 4806, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood
AU - Schnurr, Theresia M.
AU - Morgen, Camilla S.
AU - Borisevich, Dmitrii
AU - Beaumont, Robin N.
AU - Engelbrechtsen, Line
AU - Ängquist, Lars
AU - Have, Christian T.
AU - Freathy, Rachel M.
AU - Smith, George Davey
AU - Nohr, Ellen A.
AU - Hansen, Torben
AU - Sørensen, Thorkild I.A.
PY - 2020
Y1 - 2020
N2 - Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.
AB - Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role.
U2 - 10.1038/s41598-020-61719-3
DO - 10.1038/s41598-020-61719-3
M3 - Journal article
C2 - 32179833
AN - SCOPUS:85082024653
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 4806
ER -
ID: 244084795