The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion

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The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion. / Mikkelsen, U R; Paulsen, G; Schjerling, P; Helmark, I C; Langberg, Henning; Kjær, Michael; Heinemeier, K M.

I: European Journal of Applied Physiology, Bind 113, Nr. 7, 2013, s. 1883-1893.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Mikkelsen, UR, Paulsen, G, Schjerling, P, Helmark, IC, Langberg, H, Kjær, M & Heinemeier, KM 2013, 'The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion', European Journal of Applied Physiology, bind 113, nr. 7, s. 1883-1893. https://doi.org/10.1007/s00421-013-2606-y

APA

Mikkelsen, U. R., Paulsen, G., Schjerling, P., Helmark, I. C., Langberg, H., Kjær, M., & Heinemeier, K. M. (2013). The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion. European Journal of Applied Physiology, 113(7), 1883-1893. https://doi.org/10.1007/s00421-013-2606-y

Vancouver

Mikkelsen UR, Paulsen G, Schjerling P, Helmark IC, Langberg H, Kjær M o.a. The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion. European Journal of Applied Physiology. 2013;113(7):1883-1893. https://doi.org/10.1007/s00421-013-2606-y

Author

Mikkelsen, U R ; Paulsen, G ; Schjerling, P ; Helmark, I C ; Langberg, Henning ; Kjær, Michael ; Heinemeier, K M. / The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion. I: European Journal of Applied Physiology. 2013 ; Bind 113, Nr. 7. s. 1883-1893.

Bibtex

@article{401152cc65634e2bb291315b2d2ae17e,
title = "The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion",
abstract = "Non-steroidal anti-inflammatory drugs (NSAIDs) are widely consumed in relation to pain and injuries in skeletal muscle, but may adversely affect muscle adaptation probably via inhibition of prostaglandin synthesis. Induction of heat shock proteins (HSP) represents an important adaptive response in muscle subjected to stress, and in several cell types including cardiac myocytes prostaglandins are important in induction of the HSP response. This study aimed to determine the influence of NSAIDs on the HSP response to eccentric exercise in human skeletal muscle. Healthy males performed 200 maximal eccentric contractions with each leg with intramuscular infusion of the NSAID indomethacin or placebo. Biopsies were obtained from m. vastus lateralis before and after (5, 28 hrs and 8 days) the exercise bout from both legs (NSAID vs unblocked leg) and analysed for expression of the HSPs HSP70, HSP27 and aB-crystallin (mRNA and protein). NSAID did not affect the mRNA expression of any of the HSPs. Compared to pre values, the mRNA expression of all HSPs was increased; aB-crystallin, 3.6- and 5.4-fold; HSP70, 26- and 3.4-fold; and HSP27: 4.8- and 6.5-fold at 5 and 28 hrs post-exercise, respectively (all p ",
author = "Mikkelsen, {U R} and G Paulsen and P Schjerling and Helmark, {I C} and Henning Langberg and Michael Kj{\ae}r and Heinemeier, {K M}",
year = "2013",
doi = "10.1007/s00421-013-2606-y",
language = "English",
volume = "113",
pages = "1883--1893",
journal = "European Journal of Applied Physiology",
issn = "1439-6319",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion

AU - Mikkelsen, U R

AU - Paulsen, G

AU - Schjerling, P

AU - Helmark, I C

AU - Langberg, Henning

AU - Kjær, Michael

AU - Heinemeier, K M

PY - 2013

Y1 - 2013

N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) are widely consumed in relation to pain and injuries in skeletal muscle, but may adversely affect muscle adaptation probably via inhibition of prostaglandin synthesis. Induction of heat shock proteins (HSP) represents an important adaptive response in muscle subjected to stress, and in several cell types including cardiac myocytes prostaglandins are important in induction of the HSP response. This study aimed to determine the influence of NSAIDs on the HSP response to eccentric exercise in human skeletal muscle. Healthy males performed 200 maximal eccentric contractions with each leg with intramuscular infusion of the NSAID indomethacin or placebo. Biopsies were obtained from m. vastus lateralis before and after (5, 28 hrs and 8 days) the exercise bout from both legs (NSAID vs unblocked leg) and analysed for expression of the HSPs HSP70, HSP27 and aB-crystallin (mRNA and protein). NSAID did not affect the mRNA expression of any of the HSPs. Compared to pre values, the mRNA expression of all HSPs was increased; aB-crystallin, 3.6- and 5.4-fold; HSP70, 26- and 3.4-fold; and HSP27: 4.8- and 6.5-fold at 5 and 28 hrs post-exercise, respectively (all p 

AB - Non-steroidal anti-inflammatory drugs (NSAIDs) are widely consumed in relation to pain and injuries in skeletal muscle, but may adversely affect muscle adaptation probably via inhibition of prostaglandin synthesis. Induction of heat shock proteins (HSP) represents an important adaptive response in muscle subjected to stress, and in several cell types including cardiac myocytes prostaglandins are important in induction of the HSP response. This study aimed to determine the influence of NSAIDs on the HSP response to eccentric exercise in human skeletal muscle. Healthy males performed 200 maximal eccentric contractions with each leg with intramuscular infusion of the NSAID indomethacin or placebo. Biopsies were obtained from m. vastus lateralis before and after (5, 28 hrs and 8 days) the exercise bout from both legs (NSAID vs unblocked leg) and analysed for expression of the HSPs HSP70, HSP27 and aB-crystallin (mRNA and protein). NSAID did not affect the mRNA expression of any of the HSPs. Compared to pre values, the mRNA expression of all HSPs was increased; aB-crystallin, 3.6- and 5.4-fold; HSP70, 26- and 3.4-fold; and HSP27: 4.8- and 6.5-fold at 5 and 28 hrs post-exercise, respectively (all p 

U2 - 10.1007/s00421-013-2606-y

DO - 10.1007/s00421-013-2606-y

M3 - Journal article

C2 - 23467900

VL - 113

SP - 1883

EP - 1893

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

IS - 7

ER -

ID: 44832850