TY - JOUR

T1 - The health-related quality of life in hyperhidrosis and co-morbidities

AU - Henning, Mattias A. S.

AU - Ibler, Kristina S.

AU - Loft, Isabella

AU - Ostrowski, Sisse R.

AU - Erikstrup, Christian

AU - Nielsen, Kaspar R.

AU - Bruun, Mie T.

AU - Ullum, Henrik

AU - Didriksen, Maria

AU - Dinh, Khoa M.

AU - Pedersen, Ole B.

AU - Jemec, Gregor B. E.

PY - 2022/8

Y1 - 2022/8

N2 - Purpose Hyperhidrosis has been associated with a reduced health-related quality of life (HRQoL). The role of common confounding factors of this association such as stress and socioeconomic status, however, remain largely unexplored, and may affect the management strategy for hyperhidrosis. Therefore, the study objective was to compare the HRQoL in individuals with and without hyperhidrosis while adjusting for confounders. Methods In this retrospective cohort study, data on the HRQoL measured by the short-form-12 questionnaire and self-reported hyperhidrosis were collected from the Danish Blood Donor Study-cohort. Data on international classification of disease-10 codes and redeemed prescriptions were collected from nationwide registries. Linear regression investigated the association between hyperhidrosis and HRQoL. Results Total 2794 (9.1%) of 30,808 blood donors had self-reported hyperhidrosis and 284 (0.2%) of 122,225 had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 1.10; 95% confidence interval - 1.37, - 0.82; p < 0.001) and physical HRQoL (adjusted beta coefficient - 0.90; 95% confidence interval - 1.09, - 0.70; p < 0.001). Hospital diagnosed hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 0.91; 95% confidence interval - 1.82, - 0.04; p = 0.049). Conclusion Hyperhidrosis is associated with a reduced HRQoL, independently of confounders or mode of diagnosis. This supports an approach primarily targeting hyperhidrosis.

AB - Purpose Hyperhidrosis has been associated with a reduced health-related quality of life (HRQoL). The role of common confounding factors of this association such as stress and socioeconomic status, however, remain largely unexplored, and may affect the management strategy for hyperhidrosis. Therefore, the study objective was to compare the HRQoL in individuals with and without hyperhidrosis while adjusting for confounders. Methods In this retrospective cohort study, data on the HRQoL measured by the short-form-12 questionnaire and self-reported hyperhidrosis were collected from the Danish Blood Donor Study-cohort. Data on international classification of disease-10 codes and redeemed prescriptions were collected from nationwide registries. Linear regression investigated the association between hyperhidrosis and HRQoL. Results Total 2794 (9.1%) of 30,808 blood donors had self-reported hyperhidrosis and 284 (0.2%) of 122,225 had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 1.10; 95% confidence interval - 1.37, - 0.82; p < 0.001) and physical HRQoL (adjusted beta coefficient - 0.90; 95% confidence interval - 1.09, - 0.70; p < 0.001). Hospital diagnosed hyperhidrosis was associated with a reduced mental HRQoL (adjusted beta coefficient - 0.91; 95% confidence interval - 1.82, - 0.04; p = 0.049). Conclusion Hyperhidrosis is associated with a reduced HRQoL, independently of confounders or mode of diagnosis. This supports an approach primarily targeting hyperhidrosis.

KW - Hyperhidrosis

KW - Mental component summary

KW - Physical component summary

KW - Health-related quality of life

KW - PRIMARY PALMAR HYPERHIDROSIS

KW - EPIDEMIOLOGIC SURVEY

KW - VALIDATION

KW - DISABILITY

KW - QUESTIONNAIRE

KW - GENDER

KW - TRENDS

U2 - 10.1007/s11136-022-03108-z

DO - 10.1007/s11136-022-03108-z

M3 - Journal article

C2 - 35192149

VL - 31

SP - 2331

EP - 2340

JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

IS - 8

ER -