The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS): A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis

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The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS) : A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis. / Bech, Per; Allerup, Peter; Larsen, Erik Roj; Csillag, Claudio; Licht, Rasmus W.

I: Psychiatry Research, Bind 217, Nr. 3, 30.07.2014, s. 226-232.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bech, P, Allerup, P, Larsen, ER, Csillag, C & Licht, RW 2014, 'The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS): A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis', Psychiatry Research, bind 217, nr. 3, s. 226-232. https://doi.org/10.1016/j.psychres.2014.03.024

APA

Bech, P., Allerup, P., Larsen, E. R., Csillag, C., & Licht, R. W. (2014). The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS): A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis. Psychiatry Research, 217(3), 226-232. https://doi.org/10.1016/j.psychres.2014.03.024

Vancouver

Bech P, Allerup P, Larsen ER, Csillag C, Licht RW. The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS): A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis. Psychiatry Research. 2014 jul. 30;217(3):226-232. https://doi.org/10.1016/j.psychres.2014.03.024

Author

Bech, Per ; Allerup, Peter ; Larsen, Erik Roj ; Csillag, Claudio ; Licht, Rasmus W. / The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS) : A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis. I: Psychiatry Research. 2014 ; Bind 217, Nr. 3. s. 226-232.

Bibtex

@article{01c756e575bf4cff8e3c8e168810c080,
title = "The Hamilton Depression Scale (HAM-D) and the Montgomery–{\AA}sberg Depression Scale (MADRS): A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis",
abstract = "The objective of this re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study (GENDEP) was to psychometrically test the unidimensionality of the full Montgomery {\AA}sberg Depression Rating Scale (MADRS10) and the Hamilton Depression Scale (HAM-D17) versus their respective subscales (MADRS5 and HAM-D6) containing the core symptoms of depression severity. Rasch analysis was applied using RUMM 2030 software to assess the overall fit for unidimensionality. Neither the MADRS10 nor the HAM-D17 was found to fit the Rasch model for unidimensionality. The HAM-D6 (containing the items of depressed mood, guilt, work and interests, psychomotor retardation, psychic anxiety, and somatic general) as well as the analogue MADRS5 were tested for unidimensionality by use of the RUMM 2030 programme, and only the HAM-D6 was accepted. When testing for invariance across rating weeks or centres, the RUMM 2030 had to be supplemented with the Friedman two-way analysis of variance by ranks. The HAM-D6 but not the MADRS5 was accepted. It was therefore concluded that the HAM-D6 is a psychometrically valid outcome scale to measure change in clinical trials of antidepressants.",
keywords = "Adult, Analysis of Variance, Antidepressive Agents, Anxiety, Clinical Trials as Topic, Depression, Disability Evaluation, Europe, Female, Genome, Human, Humans, Male, Middle Aged, Models, Psychological, Psychiatric Status Rating Scales, Psychometrics, Reproducibility of Results, Software",
author = "Per Bech and Peter Allerup and Larsen, {Erik Roj} and Claudio Csillag and Licht, {Rasmus W}",
note = "Copyright {\textcopyright} 2014 Elsevier Ireland Ltd. All rights reserved.",
year = "2014",
month = jul,
day = "30",
doi = "10.1016/j.psychres.2014.03.024",
language = "English",
volume = "217",
pages = "226--232",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS)

T2 - A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis

AU - Bech, Per

AU - Allerup, Peter

AU - Larsen, Erik Roj

AU - Csillag, Claudio

AU - Licht, Rasmus W

N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

PY - 2014/7/30

Y1 - 2014/7/30

N2 - The objective of this re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study (GENDEP) was to psychometrically test the unidimensionality of the full Montgomery Åsberg Depression Rating Scale (MADRS10) and the Hamilton Depression Scale (HAM-D17) versus their respective subscales (MADRS5 and HAM-D6) containing the core symptoms of depression severity. Rasch analysis was applied using RUMM 2030 software to assess the overall fit for unidimensionality. Neither the MADRS10 nor the HAM-D17 was found to fit the Rasch model for unidimensionality. The HAM-D6 (containing the items of depressed mood, guilt, work and interests, psychomotor retardation, psychic anxiety, and somatic general) as well as the analogue MADRS5 were tested for unidimensionality by use of the RUMM 2030 programme, and only the HAM-D6 was accepted. When testing for invariance across rating weeks or centres, the RUMM 2030 had to be supplemented with the Friedman two-way analysis of variance by ranks. The HAM-D6 but not the MADRS5 was accepted. It was therefore concluded that the HAM-D6 is a psychometrically valid outcome scale to measure change in clinical trials of antidepressants.

AB - The objective of this re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study (GENDEP) was to psychometrically test the unidimensionality of the full Montgomery Åsberg Depression Rating Scale (MADRS10) and the Hamilton Depression Scale (HAM-D17) versus their respective subscales (MADRS5 and HAM-D6) containing the core symptoms of depression severity. Rasch analysis was applied using RUMM 2030 software to assess the overall fit for unidimensionality. Neither the MADRS10 nor the HAM-D17 was found to fit the Rasch model for unidimensionality. The HAM-D6 (containing the items of depressed mood, guilt, work and interests, psychomotor retardation, psychic anxiety, and somatic general) as well as the analogue MADRS5 were tested for unidimensionality by use of the RUMM 2030 programme, and only the HAM-D6 was accepted. When testing for invariance across rating weeks or centres, the RUMM 2030 had to be supplemented with the Friedman two-way analysis of variance by ranks. The HAM-D6 but not the MADRS5 was accepted. It was therefore concluded that the HAM-D6 is a psychometrically valid outcome scale to measure change in clinical trials of antidepressants.

KW - Adult

KW - Analysis of Variance

KW - Antidepressive Agents

KW - Anxiety

KW - Clinical Trials as Topic

KW - Depression

KW - Disability Evaluation

KW - Europe

KW - Female

KW - Genome, Human

KW - Humans

KW - Male

KW - Middle Aged

KW - Models, Psychological

KW - Psychiatric Status Rating Scales

KW - Psychometrics

KW - Reproducibility of Results

KW - Software

U2 - 10.1016/j.psychres.2014.03.024

DO - 10.1016/j.psychres.2014.03.024

M3 - Journal article

C2 - 24746391

VL - 217

SP - 226

EP - 232

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -

ID: 138818025