The functional characterization of callosal connections
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Dokumenter
- The functional characterization of callosal connections
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The brain operates through the synaptic interaction of distant neurons within flexible, often heterogeneous, distributed systems. Histological studies have detailed the connections between distant neurons, but their functional characterization deserves further exploration. Studies performed on the corpus callosum in animals and humans are unique in that they capitalize on results obtained from several neuroscience disciplines. Such data inspire a new interpretation of the function of callosal connections and delineate a novel road map, thus paving the way toward a general theory of cortico-cortical connectivity. Here we suggest that callosal axons can drive their post-synaptic targets preferentially when coupled to other inputs endowing the cortical network with a high degree of conditionality. This might depend on several factors, such as their pattern of convergence-divergence, the excitatory and inhibitory operation mode, the range of conduction velocities, the variety of homotopic and heterotopic projections and, finally, the state-dependency of their firing. We propose that, in addition to direct stimulation of post-synaptic targets, callosal axons often play a conditional driving or modulatory role, which depends on task contingencies, as documented by several recent studies.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 102186 |
| Tidsskrift | Progress in Neurobiology |
| Vol/bind | 208 |
| Antal sider | 24 |
| ISSN | 0301-0082 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
We acknowledge the support of the Istituto Italiano di Tecnologia (to R Caminiti), FONDECYT project N?1210659, Chilean fund for science and technology (to FX Aboitiz), Max Planck Society (to KE Schmidt), Natural Science and Engineering Research Council of Canada (to M Ptito), Ministry of the University and Research of Italy (PRIN 201794KEER_002 to A Battaglia-Mayer), Coll?ge de France, CNRS and LUZ Optique & Audio (to C Milleret), European Research Council (Grant. n. 339939 to CA Marzi), the CaRiPaRo Foundation (to M Caleo), Canada Research Chair in Cognitive Neuroscience and Natural Sciences and Engineering Research Council of Canada (to F Lepore). We are grateful to G. Berlucchi whose studies on callosal connections in animals and humans have powerfully motivated our own work, to K. Rockland for vigorous discussion on the manuscript, to R. Bufacchi, A. Koul, R. Somerveil, and A. M. Fitzpatrick (young researchers at the Neuroscience and Bahavior Laboratory, IIT, Rome) for their thoughtful comments to the final version of the ms. A special thanks to the many collaborators for their shared authorship in our papers. GMI was especially grateful to Jean-Philippe Thiran in whose laboratory at EPFL he enjoyed a late post-doctoral work supported by the grant SNF205320_175974.
Funding Information:
We acknowledge the support of the Istituto Italiano di Tecnologia (to R Caminiti), FONDECYT project Nº1210659, Chilean fund for science and technology (to FX Aboitiz), Max Planck Society (to KE Schmidt), Natural Science and Engineering Research Council of Canada (to M Ptito), Ministry of the University and Research of Italy (PRIN 201794KEER_002 to A Battaglia-Mayer), Collège de France, CNRS and LUZ Optique & Audio (to C Milleret), European Research Council (Grant. n. 339939 to CA Marzi), the CaRiPaRo Foundation (to M Caleo), Canada Research Chair in Cognitive Neuroscience and Natural Sciences and Engineering Research Council of Canada (to F Lepore).
Funding Information:
We are grateful to G. Berlucchi whose studies on callosal connections in animals and humans have powerfully motivated our own work, to K. Rockland for vigorous discussion on the manuscript, to R. Bufacchi, A. Koul, R. Somerveil, and A. M. Fitzpatrick (young researchers at the Neuroscience and Bahavior Laboratory, IIT, Rome) for their thoughtful comments to the final version of the ms. A special thanks to the many collaborators for their shared authorship in our papers. GMI was especially grateful to Jean-Philippe Thiran in whose laboratory at EPFL he enjoyed a late post-doctoral work supported by the grant SNF 205320_175974 .
Publisher Copyright:
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