TY - JOUR

T1 - The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men

T2 - a randomized trial

AU - Harder-Lauridsen, Nina Majlund

AU - Nielsen, Signe Tellerup

AU - Mann, Sebastian Porsdam

AU - Lyngbæk, Mark Preben

AU - Benatti, Fabiana Braga

AU - Langkilde, Annika Reynberg

AU - Law, Ian

AU - Wedell-Neergaard, Anne-Sophie

AU - Thomsen, Carsten

AU - Møller, Kirsten

AU - Karstoft, Kristian

AU - Pedersen, Bente Klarlund

AU - Krogh-Madsen, Rikke

N1 - Copyright © 2017 the American Physiological Society.

PY - 2017/2

Y1 - 2017/2

N2 - Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, V̇o2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.NEW & NOTEWORTHY: Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.

AB - Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, V̇o2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.NEW & NOTEWORTHY: Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.

KW - Adult

KW - Affect/physiology

KW - Bed Rest/adverse effects

KW - Blood Glucose/metabolism

KW - Caloric Restriction/methods

KW - Cognition/physiology

KW - Energy Metabolism/physiology

KW - Exercise/physiology

KW - Fasting/physiology

KW - Glucose/metabolism

KW - Glucose Tolerance Test/methods

KW - Humans

KW - Insulin/metabolism

KW - Insulin Resistance/physiology

KW - Intra-Abdominal Fat/metabolism

KW - Male

KW - Metabolic Syndrome/metabolism

KW - Young Adult

U2 - 10.1152/japplphysiol.00846.2016

DO - 10.1152/japplphysiol.00846.2016

M3 - Journal article

C2 - 27881670

VL - 122

SP - 230

EP - 241

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -