The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia

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Standard

The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia. / Song, Shilin; Herranz, Héctor; Cohen, Stephen M.

I: Disease Models & Mechanisms, Bind 10, Nr. 10, 2017, s. 1201-1209.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Song, S, Herranz, H & Cohen, SM 2017, 'The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia', Disease Models & Mechanisms, bind 10, nr. 10, s. 1201-1209. https://doi.org/10.1242/dmm.030122

APA

Song, S., Herranz, H., & Cohen, S. M. (2017). The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia. Disease Models & Mechanisms, 10(10), 1201-1209. https://doi.org/10.1242/dmm.030122

Vancouver

Song S, Herranz H, Cohen SM. The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia. Disease Models & Mechanisms. 2017;10(10):1201-1209. https://doi.org/10.1242/dmm.030122

Author

Song, Shilin ; Herranz, Héctor ; Cohen, Stephen M. / The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia. I: Disease Models & Mechanisms. 2017 ; Bind 10, Nr. 10. s. 1201-1209.

Bibtex

@article{d5616c0138614fd3afca1c42b8308e14,
title = "The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia",
abstract = "Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are mutated in many human cancers. In this article, we make use of a Drosophila genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI/SNF complex proteins. Members of the BAP complex exhibit tumor suppressor activity in tissue overexpressing the Yorkie (Yki) proto-oncogene, but not in tissue overexpressing epidermal growth factor receptor (EGFR). The Brahma-associated protein (BAP) complex has been reported to serve as a Yki-binding cofactor to support Yki target expression. However, we observed that depletion of BAP leads to ectopic expression of Yki targets both autonomously and non-autonomously, suggesting additional indirect effects. We provide evidence that BAP complex depletion causes upregulation of the Wingless (Wg) and Decapentaplegic (Dpp) morphogens to promote tumor formation in cooperation with Yki.",
keywords = "Cancer, Drosophila, Hippo pathway, Oncogenic cooperation, SWI/SNF, Yorkie",
author = "Shilin Song and H{\'e}ctor Herranz and Cohen, {Stephen M.}",
year = "2017",
doi = "10.1242/dmm.030122",
language = "English",
volume = "10",
pages = "1201--1209",
journal = "Disease Models & Mechanisms",
issn = "1754-8403",
publisher = "company of biologists",
number = "10",

}

RIS

TY - JOUR

T1 - The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia

AU - Song, Shilin

AU - Herranz, Héctor

AU - Cohen, Stephen M.

PY - 2017

Y1 - 2017

N2 - Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are mutated in many human cancers. In this article, we make use of a Drosophila genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI/SNF complex proteins. Members of the BAP complex exhibit tumor suppressor activity in tissue overexpressing the Yorkie (Yki) proto-oncogene, but not in tissue overexpressing epidermal growth factor receptor (EGFR). The Brahma-associated protein (BAP) complex has been reported to serve as a Yki-binding cofactor to support Yki target expression. However, we observed that depletion of BAP leads to ectopic expression of Yki targets both autonomously and non-autonomously, suggesting additional indirect effects. We provide evidence that BAP complex depletion causes upregulation of the Wingless (Wg) and Decapentaplegic (Dpp) morphogens to promote tumor formation in cooperation with Yki.

AB - Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are mutated in many human cancers. In this article, we make use of a Drosophila genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI/SNF complex proteins. Members of the BAP complex exhibit tumor suppressor activity in tissue overexpressing the Yorkie (Yki) proto-oncogene, but not in tissue overexpressing epidermal growth factor receptor (EGFR). The Brahma-associated protein (BAP) complex has been reported to serve as a Yki-binding cofactor to support Yki target expression. However, we observed that depletion of BAP leads to ectopic expression of Yki targets both autonomously and non-autonomously, suggesting additional indirect effects. We provide evidence that BAP complex depletion causes upregulation of the Wingless (Wg) and Decapentaplegic (Dpp) morphogens to promote tumor formation in cooperation with Yki.

KW - Cancer

KW - Drosophila

KW - Hippo pathway

KW - Oncogenic cooperation

KW - SWI/SNF

KW - Yorkie

U2 - 10.1242/dmm.030122

DO - 10.1242/dmm.030122

M3 - Journal article

C2 - 28754838

AN - SCOPUS:85031773842

VL - 10

SP - 1201

EP - 1209

JO - Disease Models & Mechanisms

JF - Disease Models & Mechanisms

SN - 1754-8403

IS - 10

ER -

ID: 185036595