TY - JOUR

T1 - The Association Between Fatigue and Adult Atopic Dermatitis

T2 - A Cross-Sectional Study

AU - Thyssen, Jacob P. P.

AU - Nymand, Lea K. K.

AU - Maul, Julia-Tatjana

AU - Schmid-Grendelmeier, Peter

AU - Wu, Jashin J. J.

AU - Frostrup, Anne Grete

AU - Gren, Susanne Thiesen

AU - Thomsen, Simon Francis

AU - Egeberg, Alexander

PY - 2023

Y1 - 2023

N2 - Background: There is currently limited insight into the broader impact of atopic dermatitis (AD) on mental health. Although studies indicate that AD patients may experience fatigue, no study has so far examined fatigue in more granular detail, for example, occurrence of general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue, or correlated fatigue measures with AD severity and symptoms intensity.Objectives: To examine fatigue subtypes and their prevalence in adults with AD, as well as their possible association with AD severity.Methods: A survey was conducted in adults with AD who had been managed in a hospital setting. The Patient-Oriented SCORing Atopic Dermatitis was used to determine AD severity. Patient reported outcomes, including multidimensional fatigue inventory, were included.Results: Data from 2729 adults with AD were analyzed. The total and individual fatigue scores increased consistently with lower socioeconomic scores, higher AD severity, Dermatology Life Quality Index, itch, pain, and sleep scores. Increased fatigue scores were associated with AD severity in adjusted analyses.Conclusions: Among adults with AD, fatigue scores increased with disease severity as well as intensity of AD symptoms. Fatigue is a hitherto underappreciated symptom of AD that clinicians should be cognizant about.

AB - Background: There is currently limited insight into the broader impact of atopic dermatitis (AD) on mental health. Although studies indicate that AD patients may experience fatigue, no study has so far examined fatigue in more granular detail, for example, occurrence of general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue, or correlated fatigue measures with AD severity and symptoms intensity.Objectives: To examine fatigue subtypes and their prevalence in adults with AD, as well as their possible association with AD severity.Methods: A survey was conducted in adults with AD who had been managed in a hospital setting. The Patient-Oriented SCORing Atopic Dermatitis was used to determine AD severity. Patient reported outcomes, including multidimensional fatigue inventory, were included.Results: Data from 2729 adults with AD were analyzed. The total and individual fatigue scores increased consistently with lower socioeconomic scores, higher AD severity, Dermatology Life Quality Index, itch, pain, and sleep scores. Increased fatigue scores were associated with AD severity in adjusted analyses.Conclusions: Among adults with AD, fatigue scores increased with disease severity as well as intensity of AD symptoms. Fatigue is a hitherto underappreciated symptom of AD that clinicians should be cognizant about.

KW - SLEEP

KW - DEPRESSION

KW - DISORDERS

KW - ACCIDENT

KW - ECZEMA

KW - HEALTH

U2 - 10.1089/derm.2022.0036

DO - 10.1089/derm.2022.0036

M3 - Journal article

C2 - 36724471

VL - 34

SP - 361

EP - 473

JO - Dermatitis

JF - Dermatitis

SN - 1710-3568

IS - 5

ER -