The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites

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Standard

The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites. / Jakobsen, P H; Staalsø, T; Bendtzen, K; Stürchler, D.

I: Tropical Medicine and Parasitology, Bind 46, Nr. 2, 1995, s. 88-92.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jakobsen, PH, Staalsø, T, Bendtzen, K & Stürchler, D 1995, 'The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites', Tropical Medicine and Parasitology, bind 46, nr. 2, s. 88-92.

APA

Jakobsen, P. H., Staalsø, T., Bendtzen, K., & Stürchler, D. (1995). The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites. Tropical Medicine and Parasitology, 46(2), 88-92.

Vancouver

Jakobsen PH, Staalsø T, Bendtzen K, Stürchler D. The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites. Tropical Medicine and Parasitology. 1995;46(2):88-92.

Author

Jakobsen, P H ; Staalsø, T ; Bendtzen, K ; Stürchler, D. / The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites. I: Tropical Medicine and Parasitology. 1995 ; Bind 46, Nr. 2. s. 88-92.

Bibtex

@article{334b88c01d5811df8ed1000ea68e967b,
title = "The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites",
abstract = "The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro. The biological activity of Ro 42-1611 was confirmed as it blocked Plasmodium falciparum growth in cultures. Ro 42-1611, had no major effect on TNF, IL-alpha or IL-6 cytokine release from mononuclear cells stimulated with malaria antigens or lipopolysaccharide and it did not affect cell viability. Ro 42-1611 only slightly suppressed cytoadherence of infected erythrocytes to melanoma cells. The therapeutic effect of To 42-1611 appears to be confined to its parasite killing activity.",
author = "Jakobsen, {P H} and T Staals{\o} and K Bendtzen and D St{\"u}rchler",
note = "Keywords: Adult; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Bicyclo Compounds, Heterocyclic; Cell Adhesion; Cell Survival; Chloroquine; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Humans; Immunoglobulin G; Interleukin-1; Interleukin-6; Lipopolysaccharides; Lymphocytes; Malaria, Falciparum; Mefloquine; Melanoma; Plasmodium falciparum; Styrenes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha",
year = "1995",
language = "English",
volume = "46",
pages = "88--92",
journal = "Tropical Medicine and Parasitology",
issn = "0177-2392",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites

AU - Jakobsen, P H

AU - Staalsø, T

AU - Bendtzen, K

AU - Stürchler, D

N1 - Keywords: Adult; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Bicyclo Compounds, Heterocyclic; Cell Adhesion; Cell Survival; Chloroquine; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Humans; Immunoglobulin G; Interleukin-1; Interleukin-6; Lipopolysaccharides; Lymphocytes; Malaria, Falciparum; Mefloquine; Melanoma; Plasmodium falciparum; Styrenes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

PY - 1995

Y1 - 1995

N2 - The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro. The biological activity of Ro 42-1611 was confirmed as it blocked Plasmodium falciparum growth in cultures. Ro 42-1611, had no major effect on TNF, IL-alpha or IL-6 cytokine release from mononuclear cells stimulated with malaria antigens or lipopolysaccharide and it did not affect cell viability. Ro 42-1611 only slightly suppressed cytoadherence of infected erythrocytes to melanoma cells. The therapeutic effect of To 42-1611 appears to be confined to its parasite killing activity.

AB - The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro. The biological activity of Ro 42-1611 was confirmed as it blocked Plasmodium falciparum growth in cultures. Ro 42-1611, had no major effect on TNF, IL-alpha or IL-6 cytokine release from mononuclear cells stimulated with malaria antigens or lipopolysaccharide and it did not affect cell viability. Ro 42-1611 only slightly suppressed cytoadherence of infected erythrocytes to melanoma cells. The therapeutic effect of To 42-1611 appears to be confined to its parasite killing activity.

M3 - Journal article

C2 - 8525291

VL - 46

SP - 88

EP - 92

JO - Tropical Medicine and Parasitology

JF - Tropical Medicine and Parasitology

SN - 0177-2392

IS - 2

ER -

ID: 18106381