TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
T helper (TH) 17 cells are believed to play a pivotal role in development of inflammatory bowel disease, and their contribution to intestinal inflammation has been studied in various models of colitis. TH17 cells produce a range of cytokines, some of which are potential targets for immunotherapy. However, blockade of IL-17A alone with secukinumab was not effective in Crohn's disease. In this regard, the pathogenic impact of IL-17A versus IL-17F during intestinal inflammation is still unresolved.
Originalsprog | Engelsk |
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Tidsskrift | Inflammatory Bowel Diseases |
Vol/bind | 19 |
Udgave nummer | 8 |
Sider (fra-til) | 1567-1576 |
Antal sider | 10 |
ISSN | 1078-0998 |
DOI | |
Status | Udgivet - 2013 |
ID: 47486081