TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

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Standard

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. / Williams, Kristine; Christensen, Jesper; Pedersen, Marianne Terndrup; Johansen, Jens V; Cloos, Paul A C; Rappsilber, Juri; Helin, Kristian.

I: Nature, Bind 473, Nr. 7347, 19.05.2011, s. 343-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Williams, K, Christensen, J, Pedersen, MT, Johansen, JV, Cloos, PAC, Rappsilber, J & Helin, K 2011, 'TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity', Nature, bind 473, nr. 7347, s. 343-8. https://doi.org/10.1038/nature10066

APA

Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011). TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature, 473(7347), 343-8. https://doi.org/10.1038/nature10066

Vancouver

Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PAC, Rappsilber J o.a. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011 maj 19;473(7347):343-8. https://doi.org/10.1038/nature10066

Author

Williams, Kristine ; Christensen, Jesper ; Pedersen, Marianne Terndrup ; Johansen, Jens V ; Cloos, Paul A C ; Rappsilber, Juri ; Helin, Kristian. / TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. I: Nature. 2011 ; Bind 473, Nr. 7347. s. 343-8.

Bibtex

@article{5b6a03e4f127401382f7456bfa548826,
title = "TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity",
abstract = "Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC). Here we show that TET1 binds throughout the genome of embryonic stem cells, with the majority of binding sites located at transcription start sites (TSSs) of CpG-rich promoters and within genes. The hmC modification is found in gene bodies and in contrast to mC is also enriched at CpG-rich TSSs. We provide evidence further that TET1 has a role in transcriptional repression. TET1 binds a significant proportion of Polycomb group target genes. Furthermore, TET1 associates and colocalizes with the SIN3A co-repressor complex. We propose that TET1 fine-tunes transcription, opposes aberrant DNA methylation at CpG-rich sequences and thereby contributes to the regulation of DNA methylation fidelity.",
author = "Kristine Williams and Jesper Christensen and Pedersen, {Marianne Terndrup} and Johansen, {Jens V} and Cloos, {Paul A C} and Juri Rappsilber and Kristian Helin",
year = "2011",
month = may,
day = "19",
doi = "10.1038/nature10066",
language = "English",
volume = "473",
pages = "343--8",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7347",

}

RIS

TY - JOUR

T1 - TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

AU - Williams, Kristine

AU - Christensen, Jesper

AU - Pedersen, Marianne Terndrup

AU - Johansen, Jens V

AU - Cloos, Paul A C

AU - Rappsilber, Juri

AU - Helin, Kristian

PY - 2011/5/19

Y1 - 2011/5/19

N2 - Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC). Here we show that TET1 binds throughout the genome of embryonic stem cells, with the majority of binding sites located at transcription start sites (TSSs) of CpG-rich promoters and within genes. The hmC modification is found in gene bodies and in contrast to mC is also enriched at CpG-rich TSSs. We provide evidence further that TET1 has a role in transcriptional repression. TET1 binds a significant proportion of Polycomb group target genes. Furthermore, TET1 associates and colocalizes with the SIN3A co-repressor complex. We propose that TET1 fine-tunes transcription, opposes aberrant DNA methylation at CpG-rich sequences and thereby contributes to the regulation of DNA methylation fidelity.

AB - Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC). Here we show that TET1 binds throughout the genome of embryonic stem cells, with the majority of binding sites located at transcription start sites (TSSs) of CpG-rich promoters and within genes. The hmC modification is found in gene bodies and in contrast to mC is also enriched at CpG-rich TSSs. We provide evidence further that TET1 has a role in transcriptional repression. TET1 binds a significant proportion of Polycomb group target genes. Furthermore, TET1 associates and colocalizes with the SIN3A co-repressor complex. We propose that TET1 fine-tunes transcription, opposes aberrant DNA methylation at CpG-rich sequences and thereby contributes to the regulation of DNA methylation fidelity.

U2 - 10.1038/nature10066

DO - 10.1038/nature10066

M3 - Journal article

C2 - 21490601

VL - 473

SP - 343

EP - 348

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7347

ER -

ID: 33532064