Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease
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Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease. / Binnie, Lauren R.; Pauls, Mathilde M.H.; Benjamin, Philip; Dhillon, Mohani Preet K.; Betteridge, Shai; Clarke, Brian; Ghatala, Rita; Hainsworth, Fearghal A.H.; Howe, Franklyn A.; Khan, Usman; Kruuse, Christina; Madigan, Jeremy B.; Moynihan, Barry; Patel, Bhavini; Pereira, Anthony C.; Rostrup, Egill; Shtaya, Anan B.Y.; Spilling, Catherine A.; Trippier, Sarah; Williams, Rebecca; Isaacs, Jeremy D.; Barrick, Thomas R.; Hainsworth, Atticus H.
I: Translational Stroke Research, Bind 13, Nr. 4, 2022, s. 583-594.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease
AU - Binnie, Lauren R.
AU - Pauls, Mathilde M.H.
AU - Benjamin, Philip
AU - Dhillon, Mohani Preet K.
AU - Betteridge, Shai
AU - Clarke, Brian
AU - Ghatala, Rita
AU - Hainsworth, Fearghal A.H.
AU - Howe, Franklyn A.
AU - Khan, Usman
AU - Kruuse, Christina
AU - Madigan, Jeremy B.
AU - Moynihan, Barry
AU - Patel, Bhavini
AU - Pereira, Anthony C.
AU - Rostrup, Egill
AU - Shtaya, Anan B.Y.
AU - Spilling, Catherine A.
AU - Trippier, Sarah
AU - Williams, Rebecca
AU - Isaacs, Jeremy D.
AU - Barrick, Thomas R.
AU - Hainsworth, Atticus H.
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2022
Y1 - 2022
N2 - Cerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment. Cerebral blood flow (CBF) is reduced in SVD, particularly within white matter. Here we quantified test–retest reliability in CBF measurements using pseudo-continuous arterial spin labelling (pCASL) in older adults with clinical and radiological evidence of SVD (N=54, mean (SD): 66.9 (8.7) years, 15 females/39 males). We generated whole-brain CBF maps on two visits at least 7 days apart (mean (SD): 20 (19), range 7-117 days). Test–retest reliability for CBF was high in all tissue types, with intra-class correlation coefficient [95%CI]: 0.758 [0.616, 0.852] for whole brain, 0.842 [0.743, 0.905] for total grey matter, 0.771 [0.636, 0.861] for deep grey matter (caudate-putamen and thalamus), 0.872 [0.790, 0.923] for normal-appearing white matter (NAWM) and 0.780 [0.650, 0.866] for WMH (all p<0.001). ANCOVA models indicated significant decline in CBF in total grey matter, deep grey matter and NAWM with increasing age and diastolic blood pressure (all p<0.001). CBF was lower in males relative to females (p=0.013 for total grey matter, p=0.004 for NAWM). We conclude that pCASL has high test–retest reliability as a quantitative measure of CBF in older adults with SVD. These findings support the use of pCASL in routine clinical imaging and as a clinical trial endpoint. All data come from the PASTIS trial, prospectively registered at: https://eudract.ema.europa.eu (2015-001235-20, registered 13/05/2015), http://www.clinicaltrials.gov (NCT02450253, registered 21/05/2015).
AB - Cerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment. Cerebral blood flow (CBF) is reduced in SVD, particularly within white matter. Here we quantified test–retest reliability in CBF measurements using pseudo-continuous arterial spin labelling (pCASL) in older adults with clinical and radiological evidence of SVD (N=54, mean (SD): 66.9 (8.7) years, 15 females/39 males). We generated whole-brain CBF maps on two visits at least 7 days apart (mean (SD): 20 (19), range 7-117 days). Test–retest reliability for CBF was high in all tissue types, with intra-class correlation coefficient [95%CI]: 0.758 [0.616, 0.852] for whole brain, 0.842 [0.743, 0.905] for total grey matter, 0.771 [0.636, 0.861] for deep grey matter (caudate-putamen and thalamus), 0.872 [0.790, 0.923] for normal-appearing white matter (NAWM) and 0.780 [0.650, 0.866] for WMH (all p<0.001). ANCOVA models indicated significant decline in CBF in total grey matter, deep grey matter and NAWM with increasing age and diastolic blood pressure (all p<0.001). CBF was lower in males relative to females (p=0.013 for total grey matter, p=0.004 for NAWM). We conclude that pCASL has high test–retest reliability as a quantitative measure of CBF in older adults with SVD. These findings support the use of pCASL in routine clinical imaging and as a clinical trial endpoint. All data come from the PASTIS trial, prospectively registered at: https://eudract.ema.europa.eu (2015-001235-20, registered 13/05/2015), http://www.clinicaltrials.gov (NCT02450253, registered 21/05/2015).
KW - Arterial spin labelling
KW - Cerebral blood flow
KW - Small vessel disease
KW - Vascular aging
KW - White matter lesions
U2 - 10.1007/s12975-021-00983-5
DO - 10.1007/s12975-021-00983-5
M3 - Journal article
C2 - 35080734
AN - SCOPUS:85123622282
VL - 13
SP - 583
EP - 594
JO - Translational Stroke Research
JF - Translational Stroke Research
SN - 1868-4483
IS - 4
ER -
ID: 314965652