Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells

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Standard

Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells. / Hansen, Gert Helge; Belhage, B; Schousboe, A; Meier, E.

I: International Journal of Developmental Neuroscience, Bind 5, Nr. 3, 1987, s. 263-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, GH, Belhage, B, Schousboe, A & Meier, E 1987, 'Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells', International Journal of Developmental Neuroscience, bind 5, nr. 3, s. 263-9.

APA

Hansen, G. H., Belhage, B., Schousboe, A., & Meier, E. (1987). Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells. International Journal of Developmental Neuroscience, 5(3), 263-9.

Vancouver

Hansen GH, Belhage B, Schousboe A, Meier E. Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells. International Journal of Developmental Neuroscience. 1987;5(3):263-9.

Author

Hansen, Gert Helge ; Belhage, B ; Schousboe, A ; Meier, E. / Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells. I: International Journal of Developmental Neuroscience. 1987 ; Bind 5, Nr. 3. s. 263-9.

Bibtex

@article{5a3e6d20e31211ddb5fc000ea68e967b,
title = "Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells",
abstract = "The temporal development of the effect of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) on the ultrastructure composition and GABA receptor expression in cerebellar granule cells was investigated by quantitative electron microscopy (morphometric analysis) and GABA binding assays. It was found that the cytoplasmic density of smooth endoplasmic reticulum was decreased, while the cytoplasmic density of rough endoplasmic reticulum, Golgi apparatus, vesicles and coated vesicles was greatly enhanced after exposure of the cells to THIP (150 microM) for only 1 hr. In cerebellar granule cells exposed to THIP (150 microM) for 3 hr low affinity GABA receptors were induced. These findings show that the effect of THIP on the ultrastructure composition and GABA receptor expression in cultured cerebellar granule cells may be interrelated and moreover it is likely that the turn-over of GABA receptors is extremely fast.",
author = "Hansen, {Gert Helge} and B Belhage and A Schousboe and E Meier",
note = "Keywords: Animals; Cells, Cultured; Cerebellum; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; gamma-Aminobutyric Acid",
year = "1987",
language = "English",
volume = "5",
pages = "263--9",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Pergamon Press",
number = "3",

}

RIS

TY - JOUR

T1 - Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells

AU - Hansen, Gert Helge

AU - Belhage, B

AU - Schousboe, A

AU - Meier, E

N1 - Keywords: Animals; Cells, Cultured; Cerebellum; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; gamma-Aminobutyric Acid

PY - 1987

Y1 - 1987

N2 - The temporal development of the effect of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) on the ultrastructure composition and GABA receptor expression in cerebellar granule cells was investigated by quantitative electron microscopy (morphometric analysis) and GABA binding assays. It was found that the cytoplasmic density of smooth endoplasmic reticulum was decreased, while the cytoplasmic density of rough endoplasmic reticulum, Golgi apparatus, vesicles and coated vesicles was greatly enhanced after exposure of the cells to THIP (150 microM) for only 1 hr. In cerebellar granule cells exposed to THIP (150 microM) for 3 hr low affinity GABA receptors were induced. These findings show that the effect of THIP on the ultrastructure composition and GABA receptor expression in cultured cerebellar granule cells may be interrelated and moreover it is likely that the turn-over of GABA receptors is extremely fast.

AB - The temporal development of the effect of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) on the ultrastructure composition and GABA receptor expression in cerebellar granule cells was investigated by quantitative electron microscopy (morphometric analysis) and GABA binding assays. It was found that the cytoplasmic density of smooth endoplasmic reticulum was decreased, while the cytoplasmic density of rough endoplasmic reticulum, Golgi apparatus, vesicles and coated vesicles was greatly enhanced after exposure of the cells to THIP (150 microM) for only 1 hr. In cerebellar granule cells exposed to THIP (150 microM) for 3 hr low affinity GABA receptors were induced. These findings show that the effect of THIP on the ultrastructure composition and GABA receptor expression in cultured cerebellar granule cells may be interrelated and moreover it is likely that the turn-over of GABA receptors is extremely fast.

M3 - Journal article

C2 - 2845717

VL - 5

SP - 263

EP - 269

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

IS - 3

ER -

ID: 9748517