T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A 20-month-old girl diagnosed with T-cell acute lymphoblastic leukemia was treated according to the Nordic NOPHO ALL2000 protocol. The patient developed severe immunosuppression and experienced life-threatening adenovirus infection, which was treated with ribavirin and cidofovir. α-fetoprotein was 20- to 30-fold elevated, and genetic analysis confirmed the diagnosis of ataxia telangiectasia. Despite receiving only 7 weeks of anti-leukemic therapy, she has stayed in first remission now 8 years after the diagnosis. We speculate that this could be because of increased chemosensitivity of ATM-mutated leukemic cells, adenovirus causing a direct oncolytic effect, and/or high levels of endogenous cortisol during her severe infection.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Pediatric Hematology/Oncology |
Vol/bind | 37 |
Udgave nummer | 2 |
Sider (fra-til) | 154-5 |
Antal sider | 2 |
ISSN | 1077-4114 |
DOI | |
Status | Udgivet - mar. 2015 |
ID: 162757861