Cell-to-cell communication presents an enticing target for therapeutic strategies directed towards Pseudomonas aeruginosa infections. Quorum sensing not only regulates a battery of secreted virulence factors, but is required for the establishment of surface-attached, antimicrobial resistant communities called biofilms that have been implicated in chronic infection. A range of potential targets include, signal synthesis, reception, and stability. The widespread prevalence of cell-to-cell signaling mechanisms in bacteria as well as biofilm-mediated infections suggests that developed therapeutic strategies may have wide ranging applications.