Systemic T-cell activation in acute clinically isolated optic neuritis.
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Systemic T-cell activation in acute clinically isolated optic neuritis. / Roed, Hanne; Frederiksen, Jette; Langkilde, Annika Reynberg; Sørensen, Torben Lykke; Lauritzen, Martin; Sellebjerg, Finn.
I: Journal of Neuroimmunology, Bind 162, Nr. 1-2, 2005, s. 165-172.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Systemic T-cell activation in acute clinically isolated optic neuritis.
AU - Roed, Hanne
AU - Frederiksen, Jette
AU - Langkilde, Annika Reynberg
AU - Sørensen, Torben Lykke
AU - Lauritzen, Martin
AU - Sellebjerg, Finn
PY - 2005
Y1 - 2005
N2 - We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON
AB - We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON
M3 - Journal article
VL - 162
SP - 165
EP - 172
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -
ID: 34074797