Systematic review and meta-analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Systematic review and meta-analysis : assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index. / Lo, B; Prosberg, M V; Gluud, L L; Chan, W; Leong, R W; van der List, E; van der Have, M; Sarter, H; Gower-Rousseau, C; Peyrin-Biroulet, L; Vind, I; Burisch, J.
I: Alimentary Pharmacology and Therapeutics, Bind 47, Nr. 1, 01.2018, s. 6-15.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Systematic review and meta-analysis
T2 - assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index
AU - Lo, B
AU - Prosberg, M V
AU - Gluud, L L
AU - Chan, W
AU - Leong, R W
AU - van der List, E
AU - van der Have, M
AU - Sarter, H
AU - Gower-Rousseau, C
AU - Peyrin-Biroulet, L
AU - Vind, I
AU - Burisch, J
N1 - © 2017 John Wiley & Sons Ltd.
PY - 2018/1
Y1 - 2018/1
N2 - BACKGROUND: The Inflammatory Bowel Disease Disability Index (IBD-DI) has recently been developed for patients with Crohn's disease (CD) and ulcerative colitis (UC).AIM: To assess the severity of disability and associated factors using the IBD-DI, and review the validity of the IBD-DI as a tool.METHOD: Systematic review of cross-sectional studies. Patients included had UC or CD and were classified as active, in remission, or needing surgery, biological and/or steroid treatment. We included studies assessing disability using the IBD-DI and that were captured by electronic and manual searches (January 2017). The possibility of bias was evaluated with the Newcastle-Ottawa Scale.RESULTS: Nine studies were included with 3167 patients. Comparatively, patients with active disease had higher disability rates than those in remission (SMD [CI95] = 1.49[1.11, 1.88], I(2) = 94%, P<.01), while patients on biological treatment had lower disability rates than those receiving corticosteroid treatment (SMD [CI95] = -0.22[-0.36, -0.08], I(2) = 0%, P<.01). Disease activity and unemployment were found to be associated factors. The IBD-DI scored "good" for internal consistency, "fair" to "excellent" for intra-rater reliability and "excellent" for inter-rater reliability. Construct validity was "moderately strong" to "very strong" and structural validity was found to be mainly unidimensional. The IBD-DI had excellent responsiveness, while its interpretability was only useful on a group level.CONCLUSIONS: This systematic review and meta-analysis found a significant association between disease activity, treatment received and disability; although significant heterogeneity was found. The IBD-DI is reliable and valid, but further studies are needed to measure its interpretability.
AB - BACKGROUND: The Inflammatory Bowel Disease Disability Index (IBD-DI) has recently been developed for patients with Crohn's disease (CD) and ulcerative colitis (UC).AIM: To assess the severity of disability and associated factors using the IBD-DI, and review the validity of the IBD-DI as a tool.METHOD: Systematic review of cross-sectional studies. Patients included had UC or CD and were classified as active, in remission, or needing surgery, biological and/or steroid treatment. We included studies assessing disability using the IBD-DI and that were captured by electronic and manual searches (January 2017). The possibility of bias was evaluated with the Newcastle-Ottawa Scale.RESULTS: Nine studies were included with 3167 patients. Comparatively, patients with active disease had higher disability rates than those in remission (SMD [CI95] = 1.49[1.11, 1.88], I(2) = 94%, P<.01), while patients on biological treatment had lower disability rates than those receiving corticosteroid treatment (SMD [CI95] = -0.22[-0.36, -0.08], I(2) = 0%, P<.01). Disease activity and unemployment were found to be associated factors. The IBD-DI scored "good" for internal consistency, "fair" to "excellent" for intra-rater reliability and "excellent" for inter-rater reliability. Construct validity was "moderately strong" to "very strong" and structural validity was found to be mainly unidimensional. The IBD-DI had excellent responsiveness, while its interpretability was only useful on a group level.CONCLUSIONS: This systematic review and meta-analysis found a significant association between disease activity, treatment received and disability; although significant heterogeneity was found. The IBD-DI is reliable and valid, but further studies are needed to measure its interpretability.
KW - Journal Article
KW - Review
U2 - 10.1111/apt.14373
DO - 10.1111/apt.14373
M3 - Review
C2 - 28994131
VL - 47
SP - 6
EP - 15
JO - Alimentary Pharmacology and Therapeutics, Supplement
JF - Alimentary Pharmacology and Therapeutics, Supplement
SN - 0953-0673
IS - 1
ER -
ID: 186086843