Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity

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Standard

Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity. / Hjelmgaard, Thomas; Persson, Tobias; Rasmussen, Thomas B; Givskov, Michael; Nielsen, John.

I: Bioorganic & Medicinal Chemistry, Bind 11, Nr. 15, 2003, s. 3261-71.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hjelmgaard, T, Persson, T, Rasmussen, TB, Givskov, M & Nielsen, J 2003, 'Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity', Bioorganic & Medicinal Chemistry, bind 11, nr. 15, s. 3261-71.

APA

Hjelmgaard, T., Persson, T., Rasmussen, T. B., Givskov, M., & Nielsen, J. (2003). Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity. Bioorganic & Medicinal Chemistry, 11(15), 3261-71.

Vancouver

Hjelmgaard T, Persson T, Rasmussen TB, Givskov M, Nielsen J. Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity. Bioorganic & Medicinal Chemistry. 2003;11(15):3261-71.

Author

Hjelmgaard, Thomas ; Persson, Tobias ; Rasmussen, Thomas B ; Givskov, Michael ; Nielsen, John. / Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity. I: Bioorganic & Medicinal Chemistry. 2003 ; Bind 11, Nr. 15. s. 3261-71.

Bibtex

@article{6abe9b50fcf011ddb219000ea68e967b,
title = "Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity",
abstract = "The synthesis of 5- and 3-(1'-hydroxyalkyl)-substituted 5H-furan-2-ones 4a-d and 8a-d as well as 5-alkylidene-5H-furan-2-ones 5a-d is described. A study of the structure-activity relationship of these furanone-based natural product analogues towards two different quorum sensing systems is reported. Although the synthesized compounds are not as potent quorum sensing inhibitors as some natural counterparts and a synthetic analogue hereof, interesting structure-activity relationships are seen.",
author = "Thomas Hjelmgaard and Tobias Persson and Rasmussen, {Thomas B} and Michael Givskov and John Nielsen",
note = "Keywords: Bacterial Proteins; Biological Factors; Furans",
year = "2003",
language = "English",
volume = "11",
pages = "3261--71",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "15",

}

RIS

TY - JOUR

T1 - Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity

AU - Hjelmgaard, Thomas

AU - Persson, Tobias

AU - Rasmussen, Thomas B

AU - Givskov, Michael

AU - Nielsen, John

N1 - Keywords: Bacterial Proteins; Biological Factors; Furans

PY - 2003

Y1 - 2003

N2 - The synthesis of 5- and 3-(1'-hydroxyalkyl)-substituted 5H-furan-2-ones 4a-d and 8a-d as well as 5-alkylidene-5H-furan-2-ones 5a-d is described. A study of the structure-activity relationship of these furanone-based natural product analogues towards two different quorum sensing systems is reported. Although the synthesized compounds are not as potent quorum sensing inhibitors as some natural counterparts and a synthetic analogue hereof, interesting structure-activity relationships are seen.

AB - The synthesis of 5- and 3-(1'-hydroxyalkyl)-substituted 5H-furan-2-ones 4a-d and 8a-d as well as 5-alkylidene-5H-furan-2-ones 5a-d is described. A study of the structure-activity relationship of these furanone-based natural product analogues towards two different quorum sensing systems is reported. Although the synthesized compounds are not as potent quorum sensing inhibitors as some natural counterparts and a synthetic analogue hereof, interesting structure-activity relationships are seen.

M3 - Journal article

C2 - 12837536

VL - 11

SP - 3261

EP - 3271

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 15

ER -

ID: 10615361