Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A practical and scalable 4-step route is presented for the synthesis of 4-bromo-3-fluoro-6-methoxyoquinoline and 3-fluoro-4-iodo-6-methoxyoquinoline from readily available 2,4-dichloro-3-fluoroquinoline with an overall yield of 81-85%. Halogenated quinoline building blocks have found much use in antimicrobial drug discovery, and the method reported here would be useful for the synthesis of these compounds.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Synthesis (Germany) |
Vol/bind | 46 |
Udgave nummer | 23 |
Sider (fra-til) | 3263-3267 |
Antal sider | 5 |
ISSN | 0039-7881 |
DOI | |
Status | Udgivet - 28 aug. 2014 |
Bibliografisk note
Publisher Copyright:
© Georg Thieme Verlag Stuttgart · New York.
ID: 340026011