Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study
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Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis : A cross-sectional study. / Riis, Robert Gabriel Coumine; Gudbergsen, Henrik; Henriksen, Marius; Ballegaard, Christine; Bandak, Elisabeth; Röttger, Diana; Bliddal, Henning; Hansen, Bjarke Brandt; Hangaard, Stine; Boesen, Mikael.
I: European Journal of Radiology, Bind 85, Nr. 6, 06.2016, s. 1099-1108.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis
T2 - A cross-sectional study
AU - Riis, Robert Gabriel Coumine
AU - Gudbergsen, Henrik
AU - Henriksen, Marius
AU - Ballegaard, Christine
AU - Bandak, Elisabeth
AU - Röttger, Diana
AU - Bliddal, Henning
AU - Hansen, Bjarke Brandt
AU - Hangaard, Stine
AU - Boesen, Mikael
N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - OBJECTIVES: To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis.METHODS: In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses.RESULTS: Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3kg/m(2) and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r=-0.34; p=0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between -0.21CONCLUSIONS: The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.
AB - OBJECTIVES: To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis.METHODS: In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses.RESULTS: Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3kg/m(2) and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r=-0.34; p=0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between -0.21CONCLUSIONS: The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.
KW - Aged
KW - Contrast Media
KW - Cross-Sectional Studies
KW - Female
KW - Gadolinium
KW - Heterocyclic Compounds
KW - Humans
KW - Image Enhancement
KW - Image Processing, Computer-Assisted
KW - Knee Joint
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Organometallic Compounds
KW - Osteoarthritis, Knee
KW - Pain Measurement
KW - Patella
KW - Reproducibility of Results
KW - Self Report
KW - Synovitis
KW - Comparative Study
KW - Journal Article
U2 - 10.1016/j.ejrad.2016.03.017
DO - 10.1016/j.ejrad.2016.03.017
M3 - Journal article
C2 - 27161058
VL - 85
SP - 1099
EP - 1108
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 6
ER -
ID: 176666638