Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study

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Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis : A cross-sectional study. / Riis, Robert Gabriel Coumine; Gudbergsen, Henrik; Henriksen, Marius; Ballegaard, Christine; Bandak, Elisabeth; Röttger, Diana; Bliddal, Henning; Hansen, Bjarke Brandt; Hangaard, Stine; Boesen, Mikael.

I: European Journal of Radiology, Bind 85, Nr. 6, 06.2016, s. 1099-1108.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Riis, RGC, Gudbergsen, H, Henriksen, M, Ballegaard, C, Bandak, E, Röttger, D, Bliddal, H, Hansen, BB, Hangaard, S & Boesen, M 2016, 'Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study', European Journal of Radiology, bind 85, nr. 6, s. 1099-1108. https://doi.org/10.1016/j.ejrad.2016.03.017

APA

Riis, R. G. C., Gudbergsen, H., Henriksen, M., Ballegaard, C., Bandak, E., Röttger, D., ... Boesen, M. (2016). Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study. European Journal of Radiology, 85(6), 1099-1108. https://doi.org/10.1016/j.ejrad.2016.03.017

Vancouver

Riis RGC, Gudbergsen H, Henriksen M, Ballegaard C, Bandak E, Röttger D o.a. Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study. European Journal of Radiology. 2016 jun;85(6):1099-1108. https://doi.org/10.1016/j.ejrad.2016.03.017

Author

Riis, Robert Gabriel Coumine ; Gudbergsen, Henrik ; Henriksen, Marius ; Ballegaard, Christine ; Bandak, Elisabeth ; Röttger, Diana ; Bliddal, Henning ; Hansen, Bjarke Brandt ; Hangaard, Stine ; Boesen, Mikael. / Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis : A cross-sectional study. I: European Journal of Radiology. 2016 ; Bind 85, Nr. 6. s. 1099-1108.

Bibtex

@article{987aa11a44314b979d9c2cbc5593c72f,
title = "Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study",
abstract = "OBJECTIVES: To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis.METHODS: In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses.RESULTS: Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3kg/m(2) and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r=-0.34; p=0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between -0.21CONCLUSIONS: The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.",
keywords = "Aged, Contrast Media, Cross-Sectional Studies, Female, Gadolinium, Heterocyclic Compounds, Humans, Image Enhancement, Image Processing, Computer-Assisted, Knee Joint, Magnetic Resonance Imaging, Male, Middle Aged, Organometallic Compounds, Osteoarthritis, Knee, Pain Measurement, Patella, Reproducibility of Results, Self Report, Synovitis, Comparative Study, Journal Article",
author = "Riis, {Robert Gabriel Coumine} and Henrik Gudbergsen and Marius Henriksen and Christine Ballegaard and Elisabeth Bandak and Diana R{\"o}ttger and Henning Bliddal and Hansen, {Bjarke Brandt} and Stine Hangaard and Mikael Boesen",
note = "Copyright {\circledC} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = "6",
doi = "10.1016/j.ejrad.2016.03.017",
language = "English",
volume = "85",
pages = "1099--1108",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis

T2 - A cross-sectional study

AU - Riis, Robert Gabriel Coumine

AU - Gudbergsen, Henrik

AU - Henriksen, Marius

AU - Ballegaard, Christine

AU - Bandak, Elisabeth

AU - Röttger, Diana

AU - Bliddal, Henning

AU - Hansen, Bjarke Brandt

AU - Hangaard, Stine

AU - Boesen, Mikael

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/6

Y1 - 2016/6

N2 - OBJECTIVES: To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis.METHODS: In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses.RESULTS: Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3kg/m(2) and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r=-0.34; p=0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between -0.21CONCLUSIONS: The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.

AB - OBJECTIVES: To investigate the association between pain and peripatellar-synovitis on static and dynamic contrast-enhanced MRI in knee osteoarthritis.METHODS: In a cross-sectional setting, knee synovitis was assessed using 3-Tesla MRI and correlated with pain using the knee injury and osteoarthritis outcome score (KOOS). Synovitis was assessed in the peripatellar recesses with: (i) dynamic contrast-enhanced (DCE)-MRI, using both pharmacokinetic and heuristic models, (ii) contrast-enhanced (CE)-MRI, and (iii) non-CE-MRI. The DCE-MRI variable IRExNvoxel was chosen as the primary variable in the analyses.RESULTS: Valid data were available in 94 persons with a mean age of 65 years, a BMI of 32.3kg/m(2) and a mean Kellgren-Lawrence grade of 2.5. IRExNvoxel showed a statically significant correlation with KOOS-Pain (r=-0.34; p=0.001), as was the case with all DCE-variables but one. Correlations between static MRI-variables and KOOS-Pain ranged between -0.21CONCLUSIONS: The results confirm an association between peripatellar-synovitis and pain in KOA. Overall, DCE-MRI showed stronger correlations with KOOS-Pain compared to static MRI. DCE-MRI analyses were highly reproducible and have the potential to be used to further investigate the role of inflammation and perfusion in KOA.

KW - Aged

KW - Contrast Media

KW - Cross-Sectional Studies

KW - Female

KW - Gadolinium

KW - Heterocyclic Compounds

KW - Humans

KW - Image Enhancement

KW - Image Processing, Computer-Assisted

KW - Knee Joint

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Organometallic Compounds

KW - Osteoarthritis, Knee

KW - Pain Measurement

KW - Patella

KW - Reproducibility of Results

KW - Self Report

KW - Synovitis

KW - Comparative Study

KW - Journal Article

U2 - 10.1016/j.ejrad.2016.03.017

DO - 10.1016/j.ejrad.2016.03.017

M3 - Journal article

C2 - 27161058

VL - 85

SP - 1099

EP - 1108

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 6

ER -

ID: 176666638