Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.
Originalsprog | Engelsk |
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Tidsskrift | The Journal of antimicrobial chemotherapy |
Vol/bind | 67 |
Udgave nummer | 5 |
Sider (fra-til) | 1198-206 |
Antal sider | 9 |
ISSN | 0305-7453 |
DOI | |
Status | Udgivet - maj 2012 |
ID: 105877773