Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms

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Standard

Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms. / Harms, Klaus; Lunnan, Asbjørn; Hülter, Nils; Mourier, Tobias; Vinner, Lasse; Andam, Cheryl P.; Marttinen, Pekka; Fridholm, Eva Marie Helena; Hansen, Anders Johannes; Hanage, William P.; Nielsen, Kaare Magne; Willerslev, Eske; Johnsen, Pål Jarle.

I: National Academy of Sciences. Proceedings, Bind 113, Nr. 52, 2016, s. 15066-15071.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Harms, K, Lunnan, A, Hülter, N, Mourier, T, Vinner, L, Andam, CP, Marttinen, P, Fridholm, EMH, Hansen, AJ, Hanage, WP, Nielsen, KM, Willerslev, E & Johnsen, PJ 2016, 'Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms', National Academy of Sciences. Proceedings, bind 113, nr. 52, s. 15066-15071. https://doi.org/10.1073/pnas.1615819114

APA

Harms, K., Lunnan, A., Hülter, N., Mourier, T., Vinner, L., Andam, C. P., Marttinen, P., Fridholm, E. M. H., Hansen, A. J., Hanage, W. P., Nielsen, K. M., Willerslev, E., & Johnsen, P. J. (2016). Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms. National Academy of Sciences. Proceedings, 113(52), 15066-15071. https://doi.org/10.1073/pnas.1615819114

Vancouver

Harms K, Lunnan A, Hülter N, Mourier T, Vinner L, Andam CP o.a. Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms. National Academy of Sciences. Proceedings. 2016;113(52):15066-15071. https://doi.org/10.1073/pnas.1615819114

Author

Harms, Klaus ; Lunnan, Asbjørn ; Hülter, Nils ; Mourier, Tobias ; Vinner, Lasse ; Andam, Cheryl P. ; Marttinen, Pekka ; Fridholm, Eva Marie Helena ; Hansen, Anders Johannes ; Hanage, William P. ; Nielsen, Kaare Magne ; Willerslev, Eske ; Johnsen, Pål Jarle. / Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms. I: National Academy of Sciences. Proceedings. 2016 ; Bind 113, Nr. 52. s. 15066-15071.

Bibtex

@article{716cbf1724f74af1a52f5c8355348a5d,
title = "Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms",
abstract = "In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate recombination (SPDIR), facilitates short single-stranded DNA molecules to invade and replace genomic DNA through two joint illegitimate recombination events. SPDIR is controlled by key components of the cellular genome maintenance machinery in the gram-negative bacterium Acinetobacter baylyi. The source DNA is primarily intragenomic but can also be acquired through horizontal gene transfer. The DNA replacements are nonreciprocal and locus independent. Bioinformatic approaches reveal occurrence of SPDIR events in the gram-positive human pathogen Streptococcus pneumoniae and in the human genome.",
author = "Klaus Harms and Asbj{\o}rn Lunnan and Nils H{\"u}lter and Tobias Mourier and Lasse Vinner and Andam, {Cheryl P.} and Pekka Marttinen and Fridholm, {Eva Marie Helena} and Hansen, {Anders Johannes} and Hanage, {William P.} and Nielsen, {Kaare Magne} and Eske Willerslev and Johnsen, {P{\aa}l Jarle}",
year = "2016",
doi = "10.1073/pnas.1615819114",
language = "English",
volume = "113",
pages = "15066--15071",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "52",

}

RIS

TY - JOUR

T1 - Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms

AU - Harms, Klaus

AU - Lunnan, Asbjørn

AU - Hülter, Nils

AU - Mourier, Tobias

AU - Vinner, Lasse

AU - Andam, Cheryl P.

AU - Marttinen, Pekka

AU - Fridholm, Eva Marie Helena

AU - Hansen, Anders Johannes

AU - Hanage, William P.

AU - Nielsen, Kaare Magne

AU - Willerslev, Eske

AU - Johnsen, Pål Jarle

PY - 2016

Y1 - 2016

N2 - In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate recombination (SPDIR), facilitates short single-stranded DNA molecules to invade and replace genomic DNA through two joint illegitimate recombination events. SPDIR is controlled by key components of the cellular genome maintenance machinery in the gram-negative bacterium Acinetobacter baylyi. The source DNA is primarily intragenomic but can also be acquired through horizontal gene transfer. The DNA replacements are nonreciprocal and locus independent. Bioinformatic approaches reveal occurrence of SPDIR events in the gram-positive human pathogen Streptococcus pneumoniae and in the human genome.

AB - In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate recombination (SPDIR), facilitates short single-stranded DNA molecules to invade and replace genomic DNA through two joint illegitimate recombination events. SPDIR is controlled by key components of the cellular genome maintenance machinery in the gram-negative bacterium Acinetobacter baylyi. The source DNA is primarily intragenomic but can also be acquired through horizontal gene transfer. The DNA replacements are nonreciprocal and locus independent. Bioinformatic approaches reveal occurrence of SPDIR events in the gram-positive human pathogen Streptococcus pneumoniae and in the human genome.

U2 - 10.1073/pnas.1615819114

DO - 10.1073/pnas.1615819114

M3 - Journal article

C2 - 27956618

VL - 113

SP - 15066

EP - 15071

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 52

ER -

ID: 169991828