Subfoveal Choroidal Thickness in 1323 Children Aged 11 to 12 Years and Association With Puberty: The Copenhagen Child Cohort 2000 Eye Study
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Subfoveal Choroidal Thickness in 1323 Children Aged 11 to 12 Years and Association With Puberty : The Copenhagen Child Cohort 2000 Eye Study. / Li, Xiao Qiang; Jeppesen, Pia; Larsen, Michael; Munch, Inger Christine.
I: Investigative Ophthalmology & Visual Science, Bind 55, Nr. 1, 01.2014, s. 550-555.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Subfoveal Choroidal Thickness in 1323 Children Aged 11 to 12 Years and Association With Puberty
T2 - The Copenhagen Child Cohort 2000 Eye Study
AU - Li, Xiao Qiang
AU - Jeppesen, Pia
AU - Larsen, Michael
AU - Munch, Inger Christine
PY - 2014/1
Y1 - 2014/1
N2 - PURPOSE: To investigate subfoveal choroidal thickness and ocular- and systemic-associated factors in a population-based cohort of children.METHODS: Cross-sectional, observational study where 1323 healthy 11- and 12-year-old children were examined with enhanced-depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT), ocular interferometric biometry, blood pressure manometry, and measurement of height, weight, nonmydriatic refraction, and best-corrected visual acuity. Self-reported stage of pubertal development was classified as Tanner stages 1 through 4.RESULTS: Mean subfoveal choroidal thickness was 369 ± 81 μm in girls and 348 ± 72 μm in boys. Longer axial length was associated with a thinner subfoveal choroid (-27.2 [95% confidence interval (CI) -32.7 to -21.7] μm/mm; P < 0.0001), adjusting for age and sex. There was no difference in choroidal thickness between sexes (P = 0.14) after adjusting for age and axial length. In girls, the choroid was thickest in participants in the more advanced stage of pubertal development (54.2 [95% CI 20.7-87.7] μm for Tanner 4 versus Tanner 1, P = 0.0015) and increased with body height (19.2 [95% CI 10.8-27.5] μm/10 cm, P < 0.0001). There was no effect of height or puberty in boys, who were less sexually mature than girls.CONCLUSIONS: Choroidal thickness in girls increased with body height and sexual maturation. The results suggest that puberty promotes choroidal thickening in girls, an effect that may be mediated by the pubertal growth spurt. The lack of pubertal effect in boys may be related to a smaller proportion of boys in this study having entered puberty.
AB - PURPOSE: To investigate subfoveal choroidal thickness and ocular- and systemic-associated factors in a population-based cohort of children.METHODS: Cross-sectional, observational study where 1323 healthy 11- and 12-year-old children were examined with enhanced-depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT), ocular interferometric biometry, blood pressure manometry, and measurement of height, weight, nonmydriatic refraction, and best-corrected visual acuity. Self-reported stage of pubertal development was classified as Tanner stages 1 through 4.RESULTS: Mean subfoveal choroidal thickness was 369 ± 81 μm in girls and 348 ± 72 μm in boys. Longer axial length was associated with a thinner subfoveal choroid (-27.2 [95% confidence interval (CI) -32.7 to -21.7] μm/mm; P < 0.0001), adjusting for age and sex. There was no difference in choroidal thickness between sexes (P = 0.14) after adjusting for age and axial length. In girls, the choroid was thickest in participants in the more advanced stage of pubertal development (54.2 [95% CI 20.7-87.7] μm for Tanner 4 versus Tanner 1, P = 0.0015) and increased with body height (19.2 [95% CI 10.8-27.5] μm/10 cm, P < 0.0001). There was no effect of height or puberty in boys, who were less sexually mature than girls.CONCLUSIONS: Choroidal thickness in girls increased with body height and sexual maturation. The results suggest that puberty promotes choroidal thickening in girls, an effect that may be mediated by the pubertal growth spurt. The lack of pubertal effect in boys may be related to a smaller proportion of boys in this study having entered puberty.
KW - Axial Length, Eye
KW - Child
KW - Choroid
KW - Cross-Sectional Studies
KW - Denmark
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Prospective Studies
KW - Puberty
KW - Tomography, Optical Coherence
U2 - 10.1167/iovs.13-13476
DO - 10.1167/iovs.13-13476
M3 - Journal article
C2 - 24398094
VL - 55
SP - 550
EP - 555
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
SN - 0146-0404
IS - 1
ER -
ID: 135496932