Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

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Standard

Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. / Røder, Gustav; Kristensen, Ole; Kastrup, Jette S; Buus, Søren; Gajhede, Michael.

I: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Bind 64, Nr. Pt 6, 2008, s. 459-62.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Røder, G, Kristensen, O, Kastrup, JS, Buus, S & Gajhede, M 2008, 'Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501', Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, bind 64, nr. Pt 6, s. 459-62. https://doi.org/10.1107/S1744309108012396

APA

Røder, G., Kristensen, O., Kastrup, J. S., Buus, S., & Gajhede, M. (2008). Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, 64(Pt 6), 459-62. https://doi.org/10.1107/S1744309108012396

Vancouver

Røder G, Kristensen O, Kastrup JS, Buus S, Gajhede M. Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 2008;64(Pt 6):459-62. https://doi.org/10.1107/S1744309108012396

Author

Røder, Gustav ; Kristensen, Ole ; Kastrup, Jette S ; Buus, Søren ; Gajhede, Michael. / Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. I: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 2008 ; Bind 64, Nr. Pt 6. s. 459-62.

Bibtex

@article{0fa60cf0ebc811ddbf70000ea68e967b,
title = "Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501",
abstract = "The human leukocyte antigen (HLA) class I system comprises a highly polymorphic set of molecules that specifically bind and present peptides to cytotoxic T cells. HLA-B*1501 is a prototypical member of the HLA-B62 supertype and only two peptide-HLA-B*1501 structures have been determined. Here, the crystal structure of HLA-B*1501 in complex with a SARS coronavirus-derived nonapeptide (VQQESSFVM) has been determined at high resolution (1.87 A). The peptide is deeply anchored in the B and F pockets, but with the Glu4 residue pointing away from the floor in the peptide-binding groove, making it available for interactions with a potential T-cell receptor.",
author = "Gustav R{\o}der and Ole Kristensen and Kastrup, {Jette S} and S{\o}ren Buus and Michael Gajhede",
note = "Keywords: Binding Sites; Crystallography, X-Ray; HLA-B Antigens; Histocompatibility Antigens Class I; Humans; Hydrogen Bonding; Hydrophobicity; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Oligopeptides; Protein Binding; Protein Structure, Secondary; SARS Virus; Water",
year = "2008",
doi = "10.1107/S1744309108012396",
language = "English",
volume = "64",
pages = "459--62",
journal = "Acta Crystallographica Section F: Structural Biology Communications",
issn = "2053-230X",
publisher = "Wiley",
number = "Pt 6",

}

RIS

TY - JOUR

T1 - Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

AU - Røder, Gustav

AU - Kristensen, Ole

AU - Kastrup, Jette S

AU - Buus, Søren

AU - Gajhede, Michael

N1 - Keywords: Binding Sites; Crystallography, X-Ray; HLA-B Antigens; Histocompatibility Antigens Class I; Humans; Hydrogen Bonding; Hydrophobicity; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Oligopeptides; Protein Binding; Protein Structure, Secondary; SARS Virus; Water

PY - 2008

Y1 - 2008

N2 - The human leukocyte antigen (HLA) class I system comprises a highly polymorphic set of molecules that specifically bind and present peptides to cytotoxic T cells. HLA-B*1501 is a prototypical member of the HLA-B62 supertype and only two peptide-HLA-B*1501 structures have been determined. Here, the crystal structure of HLA-B*1501 in complex with a SARS coronavirus-derived nonapeptide (VQQESSFVM) has been determined at high resolution (1.87 A). The peptide is deeply anchored in the B and F pockets, but with the Glu4 residue pointing away from the floor in the peptide-binding groove, making it available for interactions with a potential T-cell receptor.

AB - The human leukocyte antigen (HLA) class I system comprises a highly polymorphic set of molecules that specifically bind and present peptides to cytotoxic T cells. HLA-B*1501 is a prototypical member of the HLA-B62 supertype and only two peptide-HLA-B*1501 structures have been determined. Here, the crystal structure of HLA-B*1501 in complex with a SARS coronavirus-derived nonapeptide (VQQESSFVM) has been determined at high resolution (1.87 A). The peptide is deeply anchored in the B and F pockets, but with the Glu4 residue pointing away from the floor in the peptide-binding groove, making it available for interactions with a potential T-cell receptor.

U2 - 10.1107/S1744309108012396

DO - 10.1107/S1744309108012396

M3 - Journal article

C2 - 18540051

VL - 64

SP - 459

EP - 462

JO - Acta Crystallographica Section F: Structural Biology Communications

JF - Acta Crystallographica Section F: Structural Biology Communications

SN - 2053-230X

IS - Pt 6

ER -

ID: 9941869