Structural brain abnormalities in early onset first-episode psychosis
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Structural brain abnormalities in early onset first-episode psychosis. / Pagsberg, A K; Baaré, W F C; Raabjerg Christensen, A M; Fagerlund, B; Hansen, M-B; Labianca, J; Krabbe, K; Aarkrog, T; Paulson, O B; Hemmingsen, R P.
I: Journal of Neural Transmission, Bind 114, Nr. 4, 01.01.2007, s. 489-98.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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T1 - Structural brain abnormalities in early onset first-episode psychosis
AU - Pagsberg, A K
AU - Baaré, W F C
AU - Raabjerg Christensen, A M
AU - Fagerlund, B
AU - Hansen, M-B
AU - Labianca, J
AU - Krabbe, K
AU - Aarkrog, T
AU - Paulson, O B
AU - Hemmingsen, R P
PY - 2007/1/1
Y1 - 2007/1/1
N2 - BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophrenia patients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.
AB - BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophrenia patients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.
U2 - 10.1007/s00702-006-0573-8
DO - 10.1007/s00702-006-0573-8
M3 - Journal article
VL - 114
SP - 489
EP - 498
JO - Acta Neurovegetativa
JF - Acta Neurovegetativa
SN - 0375-9245
IS - 4
ER -
ID: 34084888