TY - JOUR

T1 - Source attribution of human salmonellosis using a meta-analysis of case-control studies of sporadic infections

AU - Domingues, A. R.

AU - Pires, S. M.

AU - Halasa, T.

AU - Hald, T.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Salmonella is an important cause of human illness. Disease is frequently associated with foodborne transmission, but other routes of exposure are recognized. Identifying sources of disease is essential for prioritizing public health interventions. Numerous case-control studies of sporadic salmonellosis have been published, often using different methodologies and settings. Systematic reviews consist of a formal process for literature review focused on a research question. With the objective of identifying the most important risk factors for salmonellosis, we performed a systematic review of case-control studies and a meta-analysis of obtained results. Thirty-five Salmonella case-control studies were identified. In the meta-analysis, heterogeneity between studies and possible sources of bias were investigated, and pooled odds ratios estimated. Results suggested that travel, predisposing factors, eating raw eggs, and eating in restaurants were the most important risk factors for salmonellosis. Sub-analyses by serotype were performed when enough studies were available.

AB - Salmonella is an important cause of human illness. Disease is frequently associated with foodborne transmission, but other routes of exposure are recognized. Identifying sources of disease is essential for prioritizing public health interventions. Numerous case-control studies of sporadic salmonellosis have been published, often using different methodologies and settings. Systematic reviews consist of a formal process for literature review focused on a research question. With the objective of identifying the most important risk factors for salmonellosis, we performed a systematic review of case-control studies and a meta-analysis of obtained results. Thirty-five Salmonella case-control studies were identified. In the meta-analysis, heterogeneity between studies and possible sources of bias were investigated, and pooled odds ratios estimated. Results suggested that travel, predisposing factors, eating raw eggs, and eating in restaurants were the most important risk factors for salmonellosis. Sub-analyses by serotype were performed when enough studies were available.

KW - Epidemiology

KW - food safety

KW - public health

KW - Salmonella

UR - http://www.scopus.com/inward/record.url?scp=84861014946&partnerID=8YFLogxK

U2 - 10.1017/S0950268811002172

DO - 10.1017/S0950268811002172

M3 - Review

C2 - 22152439

AN - SCOPUS:84861014946

VL - 140

SP - 959

EP - 969

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 6

ER -