Smoking is associated with infection risk in healthy blood donors

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Smoking is associated with infection risk in healthy blood donors. / Kjerulff, Bertram; Kaspersen, Kathrine A.; Dinh, Khoa M.; Boldsen, Jens; Mikkelsen, Susan; Erikstrup, Lise T.; Sørensen, Erik; Nielsen, Kaspar R.; Bruun, Mie T.; Hjalgrim, Henrik; Pedersen, Ole B.; Thørner, Lise W.; Ullum, Henrik; Ostrowski, Sisse R.; Rostgaard, Klaus; Pedersen, Carsten B.; Sigsgaard, Torben; Erikstrup, Christian.

I: Clinical Microbiology and Infection, Bind 29, Nr. 4, 2023, s. 506-514.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kjerulff, B, Kaspersen, KA, Dinh, KM, Boldsen, J, Mikkelsen, S, Erikstrup, LT, Sørensen, E, Nielsen, KR, Bruun, MT, Hjalgrim, H, Pedersen, OB, Thørner, LW, Ullum, H, Ostrowski, SR, Rostgaard, K, Pedersen, CB, Sigsgaard, T & Erikstrup, C 2023, 'Smoking is associated with infection risk in healthy blood donors', Clinical Microbiology and Infection, bind 29, nr. 4, s. 506-514. https://doi.org/10.1016/j.cmi.2022.10.020

APA

Kjerulff, B., Kaspersen, K. A., Dinh, K. M., Boldsen, J., Mikkelsen, S., Erikstrup, L. T., Sørensen, E., Nielsen, K. R., Bruun, M. T., Hjalgrim, H., Pedersen, O. B., Thørner, L. W., Ullum, H., Ostrowski, S. R., Rostgaard, K., Pedersen, C. B., Sigsgaard, T., & Erikstrup, C. (2023). Smoking is associated with infection risk in healthy blood donors. Clinical Microbiology and Infection, 29(4), 506-514. https://doi.org/10.1016/j.cmi.2022.10.020

Vancouver

Kjerulff B, Kaspersen KA, Dinh KM, Boldsen J, Mikkelsen S, Erikstrup LT o.a. Smoking is associated with infection risk in healthy blood donors. Clinical Microbiology and Infection. 2023;29(4):506-514. https://doi.org/10.1016/j.cmi.2022.10.020

Author

Kjerulff, Bertram ; Kaspersen, Kathrine A. ; Dinh, Khoa M. ; Boldsen, Jens ; Mikkelsen, Susan ; Erikstrup, Lise T. ; Sørensen, Erik ; Nielsen, Kaspar R. ; Bruun, Mie T. ; Hjalgrim, Henrik ; Pedersen, Ole B. ; Thørner, Lise W. ; Ullum, Henrik ; Ostrowski, Sisse R. ; Rostgaard, Klaus ; Pedersen, Carsten B. ; Sigsgaard, Torben ; Erikstrup, Christian. / Smoking is associated with infection risk in healthy blood donors. I: Clinical Microbiology and Infection. 2023 ; Bind 29, Nr. 4. s. 506-514.

Bibtex

@article{054944ea639444abb76672cb2bafda27,

title = "Smoking is associated with infection risk in healthy blood donors",

abstract = "Objectives: There is a gap in knowledge about the effects of smoking on overall infection risk in otherwise healthy populations, possibly leading to underestimation of the dangers of smoking. The present study aimed to examine the association of smoking with the risk of infections in a large cohort of healthy blood donors. Methods: This cohort study used questionnaire and health register data from 127 831 Danish blood donors. Multivariable Cox proportional hazards analysis was applied to estimate the association of current smoking with the risk of all-cause infection defined as hospital-based treatment for infection or filled prescriptions of antimicrobials stratified for age and adjusted for relevant confounders. Results: Among 18 272 current smokers, 12 272 filled an antimicrobial prescription and 2035 received hospital-based treatment for infections. Among 101 974 non-smokers, 65 117 filled a prescription and 8501 received hospital-based treatment for infections. Smokers had a higher risk of all-cause infection than non-smokers (hazard ratio estimates were 1.27 in males and 1.33 in females for hospital-based treatment and 1.11 in males and up to 1.20 in females for filled prescriptions). Smoking was most strongly associated with an increased incidence of respiratory tract infection, abscesses, skin infection, and prescriptions for these ailments (hazard ratio up to 2.29). Furthermore, smokers' risk of filled prescriptions of broad-spectrum penicillin was increased (hazard ratio up to 1.96). Conclusions: Current smoking was strongly associated with the risk of hospital-based treatment of infection and filled prescriptions of antimicrobials in a large cohort of healthy individuals. These findings warrant an increased focus on infectious disease risk among smokers.",

keywords = "Antimicrobial, Blood donors, Infectious disease, Smoking",

author = "Bertram Kjerulff and Kaspersen, {Kathrine A.} and Dinh, {Khoa M.} and Jens Boldsen and Susan Mikkelsen and Erikstrup, {Lise T.} and Erik S{\o}rensen and Nielsen, {Kaspar R.} and Bruun, {Mie T.} and Henrik Hjalgrim and Pedersen, {Ole B.} and Th{\o}rner, {Lise W.} and Henrik Ullum and Ostrowski, {Sisse R.} and Klaus Rostgaard and Pedersen, {Carsten B.} and Torben Sigsgaard and Christian Erikstrup",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2023",

doi = "10.1016/j.cmi.2022.10.020",

language = "English",

volume = "29",

pages = "506--514",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Smoking is associated with infection risk in healthy blood donors

AU - Kjerulff, Bertram

AU - Kaspersen, Kathrine A.

AU - Dinh, Khoa M.

AU - Boldsen, Jens

AU - Mikkelsen, Susan

AU - Erikstrup, Lise T.

AU - Sørensen, Erik

AU - Nielsen, Kaspar R.

AU - Bruun, Mie T.

AU - Hjalgrim, Henrik

AU - Pedersen, Ole B.

AU - Thørner, Lise W.

AU - Ullum, Henrik

AU - Ostrowski, Sisse R.

AU - Rostgaard, Klaus

AU - Pedersen, Carsten B.

AU - Sigsgaard, Torben

AU - Erikstrup, Christian

PY - 2023

Y1 - 2023

N2 - Objectives: There is a gap in knowledge about the effects of smoking on overall infection risk in otherwise healthy populations, possibly leading to underestimation of the dangers of smoking. The present study aimed to examine the association of smoking with the risk of infections in a large cohort of healthy blood donors. Methods: This cohort study used questionnaire and health register data from 127 831 Danish blood donors. Multivariable Cox proportional hazards analysis was applied to estimate the association of current smoking with the risk of all-cause infection defined as hospital-based treatment for infection or filled prescriptions of antimicrobials stratified for age and adjusted for relevant confounders. Results: Among 18 272 current smokers, 12 272 filled an antimicrobial prescription and 2035 received hospital-based treatment for infections. Among 101 974 non-smokers, 65 117 filled a prescription and 8501 received hospital-based treatment for infections. Smokers had a higher risk of all-cause infection than non-smokers (hazard ratio estimates were 1.27 in males and 1.33 in females for hospital-based treatment and 1.11 in males and up to 1.20 in females for filled prescriptions). Smoking was most strongly associated with an increased incidence of respiratory tract infection, abscesses, skin infection, and prescriptions for these ailments (hazard ratio up to 2.29). Furthermore, smokers' risk of filled prescriptions of broad-spectrum penicillin was increased (hazard ratio up to 1.96). Conclusions: Current smoking was strongly associated with the risk of hospital-based treatment of infection and filled prescriptions of antimicrobials in a large cohort of healthy individuals. These findings warrant an increased focus on infectious disease risk among smokers.

AB - Objectives: There is a gap in knowledge about the effects of smoking on overall infection risk in otherwise healthy populations, possibly leading to underestimation of the dangers of smoking. The present study aimed to examine the association of smoking with the risk of infections in a large cohort of healthy blood donors. Methods: This cohort study used questionnaire and health register data from 127 831 Danish blood donors. Multivariable Cox proportional hazards analysis was applied to estimate the association of current smoking with the risk of all-cause infection defined as hospital-based treatment for infection or filled prescriptions of antimicrobials stratified for age and adjusted for relevant confounders. Results: Among 18 272 current smokers, 12 272 filled an antimicrobial prescription and 2035 received hospital-based treatment for infections. Among 101 974 non-smokers, 65 117 filled a prescription and 8501 received hospital-based treatment for infections. Smokers had a higher risk of all-cause infection than non-smokers (hazard ratio estimates were 1.27 in males and 1.33 in females for hospital-based treatment and 1.11 in males and up to 1.20 in females for filled prescriptions). Smoking was most strongly associated with an increased incidence of respiratory tract infection, abscesses, skin infection, and prescriptions for these ailments (hazard ratio up to 2.29). Furthermore, smokers' risk of filled prescriptions of broad-spectrum penicillin was increased (hazard ratio up to 1.96). Conclusions: Current smoking was strongly associated with the risk of hospital-based treatment of infection and filled prescriptions of antimicrobials in a large cohort of healthy individuals. These findings warrant an increased focus on infectious disease risk among smokers.

KW - Antimicrobial

KW - Blood donors

KW - Infectious disease

KW - Smoking

U2 - 10.1016/j.cmi.2022.10.020

DO - 10.1016/j.cmi.2022.10.020

M3 - Journal article

C2 - 36404421

AN - SCOPUS:85142888948

VL - 29

SP - 506

EP - 514

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 4

ER -

ID: 335098642