Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 4,68 MB, PDF-dokument
Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 101190 |
| Tidsskrift | Cell Reports Medicine |
| Vol/bind | 4 |
| Udgave nummer | 9 |
| Antal sider | 16 |
| ISSN | 2666-3791 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This work was conducted by an expert group (EG) of ILSI Europe. Composition of the EG is listed on the ILSI Europe website at https://ilsi.eu/scientific-activities/nutrition/probiotics/. ILSI Europe facilitated scientific meetings and coordinated the overall project management and administrative tasks relating to the completion of this work. This manuscript was copy edited by Cath Mersh. Traveling and accommodation expenses were covered by ILSI Europe. All authors contributed to design and writing of the first manuscript draft. B.A.H.J. and A.C.O. led the process of editing and contextualizing the body text while integrating the contributions of each individual author. B.A.H.J. was responsible for the final editing of the manuscript. First and last authors are positioned according to standard guidelines. Remaining authors are ordered alphabetically, emphasizing the joint effort. A.C.O. M.N. B.P. D.S. L.G.W.S. and P.V.D.A. work full time for IFF, ADM, Yakult, Novozymes, Caelus Health, and Cryptobiotix respectively. These companies were not involved in carrying out this research.
Publisher Copyright:
© 2023 The Authors
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 369136130