Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls
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Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls. / Berg, Anna Korsgaard; Grauslund, Annemarie Cecilie; Nørgaard, Kirsten; Thorsen, Steffen Ullitz; Zachariae, Claus; Halling, Anne Sofie; Jakasa, Ivone; Kezic, Sanja; Svensson, Jannet; Thyssen, Jacob P.
I: JID Innovations, Bind 3, Nr. 4, 100200, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls
AU - Berg, Anna Korsgaard
AU - Grauslund, Annemarie Cecilie
AU - Nørgaard, Kirsten
AU - Thorsen, Steffen Ullitz
AU - Zachariae, Claus
AU - Halling, Anne Sofie
AU - Jakasa, Ivone
AU - Kezic, Sanja
AU - Svensson, Jannet
AU - Thyssen, Jacob P.
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Contact dermatitis because of use of diabetes devices is frequent in individuals with type 1 diabetes (TD1), especially in the pediatric age group, but the putative role of a constitutional impaired skin barrier in persons with TD1 is unclear. This study examined the skin barrier function by the measurement of natural moisturizing factor and free cytokines collected through skin tape strips, as well as biophysical markers and the skin microbiome, in persons with TD1 than to age- and sex-matched healthy controls. All measurements were done in nonlesional skin. We found that the skin barrier function was similar in children and adolescents with TD1 than to controls but found that the beta-diversity of skin microbiome at the buttock differed between the two groups. We conclude that individuals with TD1 have normal skin barrier function, and that the increased occurrence of contact dermatitis following pump and sensor use is explained by exogenous factors.
AB - Contact dermatitis because of use of diabetes devices is frequent in individuals with type 1 diabetes (TD1), especially in the pediatric age group, but the putative role of a constitutional impaired skin barrier in persons with TD1 is unclear. This study examined the skin barrier function by the measurement of natural moisturizing factor and free cytokines collected through skin tape strips, as well as biophysical markers and the skin microbiome, in persons with TD1 than to age- and sex-matched healthy controls. All measurements were done in nonlesional skin. We found that the skin barrier function was similar in children and adolescents with TD1 than to controls but found that the beta-diversity of skin microbiome at the buttock differed between the two groups. We conclude that individuals with TD1 have normal skin barrier function, and that the increased occurrence of contact dermatitis following pump and sensor use is explained by exogenous factors.
U2 - 10.1016/j.xjidi.2023.100200
DO - 10.1016/j.xjidi.2023.100200
M3 - Journal article
C2 - 37205305
AN - SCOPUS:85147925254
VL - 3
JO - JID Innovations
JF - JID Innovations
SN - 2667-0267
IS - 4
M1 - 100200
ER -
ID: 387031723