Significance of myofibroblasts in oral squamous cell carcinoma

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Significance of myofibroblasts in oral squamous cell carcinoma. / Thode, Christenze; Jørgensen, Trine G.; Dabelsteen, Erik; Mackenzie, Ian; Dabelsteen, Sally.

I: Journal of Oral Pathology & Medicine, Bind 40, Nr. 3, 01.03.2011, s. 201-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Thode, C, Jørgensen, TG, Dabelsteen, E, Mackenzie, I & Dabelsteen, S 2011, 'Significance of myofibroblasts in oral squamous cell carcinoma', Journal of Oral Pathology & Medicine, bind 40, nr. 3, s. 201-7. https://doi.org/10.1111/j.1600-0714.2010.00999.x

APA

Thode, C., Jørgensen, T. G., Dabelsteen, E., Mackenzie, I., & Dabelsteen, S. (2011). Significance of myofibroblasts in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 40(3), 201-7. https://doi.org/10.1111/j.1600-0714.2010.00999.x

Vancouver

Thode C, Jørgensen TG, Dabelsteen E, Mackenzie I, Dabelsteen S. Significance of myofibroblasts in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine. 2011 mar. 1;40(3):201-7. https://doi.org/10.1111/j.1600-0714.2010.00999.x

Author

Thode, Christenze ; Jørgensen, Trine G. ; Dabelsteen, Erik ; Mackenzie, Ian ; Dabelsteen, Sally. / Significance of myofibroblasts in oral squamous cell carcinoma. I: Journal of Oral Pathology & Medicine. 2011 ; Bind 40, Nr. 3. s. 201-7.

Bibtex

@article{30a568a014d649a0a76fe2391f0a828e,

title = "Significance of myofibroblasts in oral squamous cell carcinoma",

abstract = "It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are a-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.",

keywords = "Actins, Carcinoma, Squamous Cell, Chemokines, Disease Progression, Endothelial Cells, Extracellular Matrix Proteins, Fibroblasts, Humans, Mouth Neoplasms, Myofibroblasts, Prognosis, Stromal Cells, Tumor Microenvironment",

author = "Christenze Thode and J{\o}rgensen, {Trine G.} and Erik Dabelsteen and Ian Mackenzie and Sally Dabelsteen",

note = "{\textcopyright} 2011 John Wiley & Sons A/S.",

year = "2011",

month = mar,

day = "1",

doi = "10.1111/j.1600-0714.2010.00999.x",

language = "English",

volume = "40",

pages = "201--7",

journal = "Journal of Oral Pathology and Medicine",

issn = "0904-2512",

publisher = "Wiley-Blackwell",

number = "3",

}

RIS

TY - JOUR

T1 - Significance of myofibroblasts in oral squamous cell carcinoma

AU - Thode, Christenze

AU - Jørgensen, Trine G.

AU - Dabelsteen, Erik

AU - Mackenzie, Ian

AU - Dabelsteen, Sally

PY - 2011/3/1

Y1 - 2011/3/1

N2 - It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are a-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.

AB - It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are a-smooth muscle actin-positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis.

KW - Actins

KW - Carcinoma, Squamous Cell

KW - Chemokines

KW - Disease Progression

KW - Endothelial Cells

KW - Extracellular Matrix Proteins

KW - Fibroblasts

KW - Humans

KW - Mouth Neoplasms

KW - Myofibroblasts

KW - Prognosis

KW - Stromal Cells

KW - Tumor Microenvironment

U2 - 10.1111/j.1600-0714.2010.00999.x

DO - 10.1111/j.1600-0714.2010.00999.x

M3 - Journal article

C2 - 21342271

VL - 40

SP - 201

EP - 207

JO - Journal of Oral Pathology and Medicine

JF - Journal of Oral Pathology and Medicine

SN - 0904-2512

IS - 3

ER -

ID: 33773425