Shot-noise limited, supercontinuum-based optical coherence tomography
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Shot-noise limited, supercontinuum-based optical coherence tomography. / Rao D. S, Shreesha; Jensen, Mikkel; Grüner-Nielsen, Lars; Olsen, Jesper Toft; Heiduschka, Peter; Kemper, Björn; Schnekenburger, Jürgen; Glud, Martin; Mogensen, Mette; Israelsen, Niels Møller; Bang, Ole.
I: Light: Science and Applications, Bind 10, Nr. 1, 133, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Shot-noise limited, supercontinuum-based optical coherence tomography
AU - Rao D. S, Shreesha
AU - Jensen, Mikkel
AU - Grüner-Nielsen, Lars
AU - Olsen, Jesper Toft
AU - Heiduschka, Peter
AU - Kemper, Björn
AU - Schnekenburger, Jürgen
AU - Glud, Martin
AU - Mogensen, Mette
AU - Israelsen, Niels Møller
AU - Bang, Ole
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage, we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber, pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast, better sensitivity, and improved penetration. From SD-OCT imaging of skin, retina, and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection.
AB - We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage, we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber, pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast, better sensitivity, and improved penetration. From SD-OCT imaging of skin, retina, and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection.
U2 - 10.1038/s41377-021-00574-x
DO - 10.1038/s41377-021-00574-x
M3 - Journal article
C2 - 34183643
AN - SCOPUS:85111141112
VL - 10
JO - Light: Science and Applications
JF - Light: Science and Applications
SN - 2095-5545
IS - 1
M1 - 133
ER -
ID: 302460257