Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II
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Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II. / Silajdzija, Elvira; Bliddal, Sofie; Borgwardt, Line; Rossing, Maria; Jarløv, Anne; Nielsen, Claus Henrik; Feldt-Rasmussen, Ulla.
I: Hormones, Bind 21, Nr. 2, 2022, s. 317-322.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II
AU - Silajdzija, Elvira
AU - Bliddal, Sofie
AU - Borgwardt, Line
AU - Rossing, Maria
AU - Jarløv, Anne
AU - Nielsen, Claus Henrik
AU - Feldt-Rasmussen, Ulla
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - Background: Autoimmune disease, including autoimmune thyroid disease, with uncharacteristic symptoms can be due to additional severe disease. We report a life-threatening debut of autoimmune polyglandular syndrome type II (APS II) defined as Addison’s disease combined with autoimmune diabetes and/or thyroid disease. Patient findings: A 33-year-old male with newly diagnosed hypothyroidism was referred to a tertiary center due to fatigue and 20-kg rapid weight loss. Malignancy was excluded. After a gastroscopy, he developed Addison’s crisis; he was admitted to our hospital and stabilized. Final diagnoses included Hashimoto’s thyroiditis, Addison’s disease, vitiligo, and pernicious anemia. Whole genome sequencing found no genetic variants associated with component diseases. Human leukocyte antigen typing revealed DR3/DR4 and DQ8/DQ2 heterozygosity associated with APS II. Summary: A patient with Hashimoto’s thyroiditis and weight loss presented with Addison’s crisis and was diagnosed with APS II. Conclusions: Awareness of potential polyautoimmunity in clinical evaluation of patients with thyroid disease improves diagnosis and can be lifesaving.
AB - Background: Autoimmune disease, including autoimmune thyroid disease, with uncharacteristic symptoms can be due to additional severe disease. We report a life-threatening debut of autoimmune polyglandular syndrome type II (APS II) defined as Addison’s disease combined with autoimmune diabetes and/or thyroid disease. Patient findings: A 33-year-old male with newly diagnosed hypothyroidism was referred to a tertiary center due to fatigue and 20-kg rapid weight loss. Malignancy was excluded. After a gastroscopy, he developed Addison’s crisis; he was admitted to our hospital and stabilized. Final diagnoses included Hashimoto’s thyroiditis, Addison’s disease, vitiligo, and pernicious anemia. Whole genome sequencing found no genetic variants associated with component diseases. Human leukocyte antigen typing revealed DR3/DR4 and DQ8/DQ2 heterozygosity associated with APS II. Summary: A patient with Hashimoto’s thyroiditis and weight loss presented with Addison’s crisis and was diagnosed with APS II. Conclusions: Awareness of potential polyautoimmunity in clinical evaluation of patients with thyroid disease improves diagnosis and can be lifesaving.
KW - Addison’s disease
KW - Autoimmune polyglandular syndrome type II
KW - Autoimmunity
KW - Diabetes
KW - HLA
KW - Hypothyroidism
UR - http://www.scopus.com/inward/record.url?scp=85125807908&partnerID=8YFLogxK
U2 - 10.1007/s42000-021-00344-9
DO - 10.1007/s42000-021-00344-9
M3 - Journal article
C2 - 35182386
AN - SCOPUS:85125807908
VL - 21
SP - 317
EP - 322
JO - Hormones
JF - Hormones
SN - 1109-3099
IS - 2
ER -
ID: 319601041