Serum lactate dehydrogenase isoenzyme 1 in patients with seminoma stage I followed with surveillance
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Serum lactate dehydrogenase isoenzyme 1 in patients with seminoma stage I followed with surveillance. / von Eyben, Finn Edler; Madsen, Ebbe Lindegaard; Blaabjerg, Ole; Petersen, Per Hyltoft; Jacobsen, Grete Krag; Specht, Lena; Pedersen, Bent Nørgaard; von der Maase, Hans.
I: Acta Oncologica, Bind 41, Nr. 1, 2002, s. 77-83.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Serum lactate dehydrogenase isoenzyme 1 in patients with seminoma stage I followed with surveillance
AU - von Eyben, Finn Edler
AU - Madsen, Ebbe Lindegaard
AU - Blaabjerg, Ole
AU - Petersen, Per Hyltoft
AU - Jacobsen, Grete Krag
AU - Specht, Lena
AU - Pedersen, Bent Nørgaard
AU - von der Maase, Hans
N1 - Keywords: Adult; Aged; Carcinoma; Chorionic Gonadotropin; Disease-Free Survival; Follow-Up Studies; Humans; Isoenzymes; L-Lactate Dehydrogenase; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Orchiectomy; Preoperative Care; Seminoma; Spermatocytes; Survival Rate; Testicular Neoplasms; alpha-Fetoproteins
PY - 2002
Y1 - 2002
N2 - Serum lactate dehydrogenase isoenzyme I catalytic concentration (S-LD-1) was measured in patients with testicular seminoma clinical stage I followed with surveillance after orchiectomy. The serum samples were obtained before orchiectomy in 110 patients (group A) and soon after orchiectomy in 55 patients (group B). In group A, 60 patients (55%) had elevated S-LD-1 and 10 patients (9%) had elevated serum human chorionic gonadotropin concentrations (S-hCG). In group B, median S-LD-1 was lower than that of group A and decreased with increasing time after orchiectomv (p = 0.001, Jonckheere-Terpstra test, one-sided). After a median follow-up of 5.1 years, 23 patients (21%) in group A had relapses. The patients with elevated S-LD-1 and those with normal S-LD-1 had a similar relapse-free survival (p = 0.79, log-rank test). Thus patients with seminoma stage I had elevated S-LD-1 more often than elevated S-hCG but an elevation in S-LD-1 did not predict a relapse during follow-up with surveillance. Further studies are required to elucidate the value of S-LD-1 in monitoring the surveillance of patients with seminoma stage I.
AB - Serum lactate dehydrogenase isoenzyme I catalytic concentration (S-LD-1) was measured in patients with testicular seminoma clinical stage I followed with surveillance after orchiectomy. The serum samples were obtained before orchiectomy in 110 patients (group A) and soon after orchiectomy in 55 patients (group B). In group A, 60 patients (55%) had elevated S-LD-1 and 10 patients (9%) had elevated serum human chorionic gonadotropin concentrations (S-hCG). In group B, median S-LD-1 was lower than that of group A and decreased with increasing time after orchiectomv (p = 0.001, Jonckheere-Terpstra test, one-sided). After a median follow-up of 5.1 years, 23 patients (21%) in group A had relapses. The patients with elevated S-LD-1 and those with normal S-LD-1 had a similar relapse-free survival (p = 0.79, log-rank test). Thus patients with seminoma stage I had elevated S-LD-1 more often than elevated S-hCG but an elevation in S-LD-1 did not predict a relapse during follow-up with surveillance. Further studies are required to elucidate the value of S-LD-1 in monitoring the surveillance of patients with seminoma stage I.
M3 - Journal article
C2 - 11990523
VL - 41
SP - 77
EP - 83
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 1
ER -
ID: 19368805