Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature. / Yasmeen, Saiqa; Melchior, Linea; Bertelsen, Birgitte; Skov, Liselotte; Debes, Nanette Mol; Tümer, Zeynep.

I: Psychiatric Genetics, Bind 23, Nr. 3, 06.2013, s. 130-3.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Yasmeen, S, Melchior, L, Bertelsen, B, Skov, L, Debes, NM & Tümer, Z 2013, 'Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature', Psychiatric Genetics, bind 23, nr. 3, s. 130-3. https://doi.org/10.1097/YPG.0b013e328360c880

APA

Yasmeen, S., Melchior, L., Bertelsen, B., Skov, L., Debes, N. M., & Tümer, Z. (2013). Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature. Psychiatric Genetics, 23(3), 130-3. https://doi.org/10.1097/YPG.0b013e328360c880

Vancouver

Yasmeen S, Melchior L, Bertelsen B, Skov L, Debes NM, Tümer Z. Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature. Psychiatric Genetics. 2013 jun.;23(3):130-3. https://doi.org/10.1097/YPG.0b013e328360c880

Author

Yasmeen, Saiqa ; Melchior, Linea ; Bertelsen, Birgitte ; Skov, Liselotte ; Debes, Nanette Mol ; Tümer, Zeynep. / Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature. I: Psychiatric Genetics. 2013 ; Bind 23, Nr. 3. s. 130-3.

Bibtex

@article{fb71070d9d914119a6c267cb8c312448,
title = "Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature",
abstract = "Tourette syndrome (TS) is a complex neuropsychiatric disorder characterized by multiple motor and vocal tics and is often accompanied by comorbidities such as attention deficit hyperactivity disorder and obsessive-compulsive disorder. The complex etiology of TS and its co-occurrence with other disorders impedes linking genetic changes with disease segregation. One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes. One of these variations, which has been reported in six unrelated TS patients, was a noncoding variant (var321) at the 3'-untranslated region of SLITRK1 within a conserved binding site for microRNA has-mir-189. To elucidate the potential role of var321 in disease pathogenesis, a cohort of 112 deeply phenotyped Danish TS patients was investigated for this variation. We could not detect var321 in the present cohort, suggesting that this is not a common variant among Danish TS patients.",
author = "Saiqa Yasmeen and Linea Melchior and Birgitte Bertelsen and Liselotte Skov and Debes, {Nanette Mol} and Zeynep T{\"u}mer",
year = "2013",
month = jun,
doi = "10.1097/YPG.0b013e328360c880",
language = "English",
volume = "23",
pages = "130--3",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature

AU - Yasmeen, Saiqa

AU - Melchior, Linea

AU - Bertelsen, Birgitte

AU - Skov, Liselotte

AU - Debes, Nanette Mol

AU - Tümer, Zeynep

PY - 2013/6

Y1 - 2013/6

N2 - Tourette syndrome (TS) is a complex neuropsychiatric disorder characterized by multiple motor and vocal tics and is often accompanied by comorbidities such as attention deficit hyperactivity disorder and obsessive-compulsive disorder. The complex etiology of TS and its co-occurrence with other disorders impedes linking genetic changes with disease segregation. One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes. One of these variations, which has been reported in six unrelated TS patients, was a noncoding variant (var321) at the 3'-untranslated region of SLITRK1 within a conserved binding site for microRNA has-mir-189. To elucidate the potential role of var321 in disease pathogenesis, a cohort of 112 deeply phenotyped Danish TS patients was investigated for this variation. We could not detect var321 in the present cohort, suggesting that this is not a common variant among Danish TS patients.

AB - Tourette syndrome (TS) is a complex neuropsychiatric disorder characterized by multiple motor and vocal tics and is often accompanied by comorbidities such as attention deficit hyperactivity disorder and obsessive-compulsive disorder. The complex etiology of TS and its co-occurrence with other disorders impedes linking genetic changes with disease segregation. One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes. One of these variations, which has been reported in six unrelated TS patients, was a noncoding variant (var321) at the 3'-untranslated region of SLITRK1 within a conserved binding site for microRNA has-mir-189. To elucidate the potential role of var321 in disease pathogenesis, a cohort of 112 deeply phenotyped Danish TS patients was investigated for this variation. We could not detect var321 in the present cohort, suggesting that this is not a common variant among Danish TS patients.

U2 - 10.1097/YPG.0b013e328360c880

DO - 10.1097/YPG.0b013e328360c880

M3 - Journal article

C2 - 23528612

VL - 23

SP - 130

EP - 133

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 3

ER -

ID: 45667492