Self-reported diseases and symptoms by rupture status among unselected Danish women with cosmetic silicone breast implants
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Self-reported diseases and symptoms by rupture status among unselected Danish women with cosmetic silicone breast implants. / Hölmich, Lisbet R; Kjøller, Kim; Fryzek, Jon P; Høier-Madsen, Mimi; Vejborg, Ilse; Conrad, Carsten; Sletting, Susanne; McLaughlin, Joseph K; Breiting, Vibeke; Friis, Søren.
I: Plastic and Reconstructive Surgery, Bind 111, Nr. 2, 02.2003, s. 723-32; discussion 733-4.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Self-reported diseases and symptoms by rupture status among unselected Danish women with cosmetic silicone breast implants
AU - Hölmich, Lisbet R
AU - Kjøller, Kim
AU - Fryzek, Jon P
AU - Høier-Madsen, Mimi
AU - Vejborg, Ilse
AU - Conrad, Carsten
AU - Sletting, Susanne
AU - McLaughlin, Joseph K
AU - Breiting, Vibeke
AU - Friis, Søren
PY - 2003/2
Y1 - 2003/2
N2 - Epidemiologic evidence does not support an association between silicone breast implants and connective tissue or other rheumatic diseases. However, a recent study has suggested that women with ruptured implants may be at increased risk of developing fibromyalgia. An analysis of adverse health outcomes according to breast implant rupture status was conducted in 238 unselected Danish women with cosmetic silicone breast implants. Ninety-two of the women had definite implant rupture, and 146 had intact implants as determined by magnetic resonance imaging. Before undergoing imaging, the women provided blood samples and completed a self-administered questionnaire. Women with ruptured implants overall, and the subgroup with extracapsular ruptures (n = 23), were compared with women with intact implants regarding a number of self-reported diseases and symptoms and the presence of specific autoantibodies, such as antinuclear antibodies, rheumatoid factor, and cardiolipin immunoglobulin G and M antibodies. Overall, there were no differences in the occurrence of self-reported diseases or symptoms or in the presence of autoantibodies between women with intact implants and women with ruptured implants, including extracapsular rupture. The only exception was capsular contracture, which was reported six times more frequently by women with extracapsular ruptures than by women with intact implants (OR, 6.3; 95 percent CI, 1.7 to 23.5). In conclusion, this study of unselected women with silicone breast implants could establish no association between silicone implant rupture and specific diseases or symptoms related to connective tissue disease or other rheumatic conditions, except for an excess of capsular contracture among women with extracapsular rupture.
AB - Epidemiologic evidence does not support an association between silicone breast implants and connective tissue or other rheumatic diseases. However, a recent study has suggested that women with ruptured implants may be at increased risk of developing fibromyalgia. An analysis of adverse health outcomes according to breast implant rupture status was conducted in 238 unselected Danish women with cosmetic silicone breast implants. Ninety-two of the women had definite implant rupture, and 146 had intact implants as determined by magnetic resonance imaging. Before undergoing imaging, the women provided blood samples and completed a self-administered questionnaire. Women with ruptured implants overall, and the subgroup with extracapsular ruptures (n = 23), were compared with women with intact implants regarding a number of self-reported diseases and symptoms and the presence of specific autoantibodies, such as antinuclear antibodies, rheumatoid factor, and cardiolipin immunoglobulin G and M antibodies. Overall, there were no differences in the occurrence of self-reported diseases or symptoms or in the presence of autoantibodies between women with intact implants and women with ruptured implants, including extracapsular rupture. The only exception was capsular contracture, which was reported six times more frequently by women with extracapsular ruptures than by women with intact implants (OR, 6.3; 95 percent CI, 1.7 to 23.5). In conclusion, this study of unselected women with silicone breast implants could establish no association between silicone implant rupture and specific diseases or symptoms related to connective tissue disease or other rheumatic conditions, except for an excess of capsular contracture among women with extracapsular rupture.
KW - Adult
KW - Aged
KW - Breast Implants/adverse effects
KW - Connective Tissue Diseases/diagnosis
KW - Cross-Sectional Studies
KW - Denmark
KW - Equipment Failure Analysis/statistics & numerical data
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Middle Aged
KW - Postoperative Complications/diagnosis
KW - Prosthesis Design
KW - Rheumatic Diseases/diagnosis
KW - Rupture, Spontaneous
KW - Silicone Gels/adverse effects
U2 - 10.1097/01.PRS.0000041442.53735.F8
DO - 10.1097/01.PRS.0000041442.53735.F8
M3 - Journal article
C2 - 12560693
VL - 111
SP - 723-32; discussion 733-4
JO - Plastic and Reconstructive Surgery
JF - Plastic and Reconstructive Surgery
SN - 0032-1052
IS - 2
ER -
ID: 260412600