Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing

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Standard

Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. / Colombani, Julien; Andersen, Ditte S; Léopold, Pierre.

I: Science (New York, N.Y.), Bind 336, Nr. 6081, 04.05.2012, s. 582-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Colombani, J, Andersen, DS & Léopold, P 2012, 'Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing', Science (New York, N.Y.), bind 336, nr. 6081, s. 582-5. https://doi.org/10.1126/science.1216689

APA

Colombani, J., Andersen, D. S., & Léopold, P. (2012). Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science (New York, N.Y.), 336(6081), 582-5. https://doi.org/10.1126/science.1216689

Vancouver

Colombani J, Andersen DS, Léopold P. Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science (New York, N.Y.). 2012 maj 4;336(6081):582-5. https://doi.org/10.1126/science.1216689

Author

Colombani, Julien ; Andersen, Ditte S ; Léopold, Pierre. / Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. I: Science (New York, N.Y.). 2012 ; Bind 336, Nr. 6081. s. 582-5.

Bibtex

@article{462cc1f8839d4b889dd52c8c817b57f7,

title = "Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing",

abstract = "Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.",

keywords = "Animals, Brain/metabolism, Drosophila Proteins/genetics, Drosophila melanogaster/genetics, Ecdysone/biosynthesis, Gene Expression Regulation, Developmental, Genes, Insect, Imaginal Discs/growth & development, Intercellular Signaling Peptides and Proteins/genetics, JNK Mitogen-Activated Protein Kinases/metabolism, Larva/genetics, MAP Kinase Signaling System, Metamorphosis, Biological, RNA Interference, Sequence Deletion, Time Factors, Wings, Animal/growth & development",

author = "Julien Colombani and Andersen, {Ditte S} and Pierre L{\'e}opold",

year = "2012",

month = may,

day = "4",

doi = "10.1126/science.1216689",

language = "English",

volume = "336",

pages = "582--5",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6081",

}

RIS

TY - JOUR

T1 - Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing

AU - Colombani, Julien

AU - Andersen, Ditte S

AU - Léopold, Pierre

PY - 2012/5/4

Y1 - 2012/5/4

N2 - Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.

AB - Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.

KW - Animals

KW - Brain/metabolism

KW - Drosophila Proteins/genetics

KW - Drosophila melanogaster/genetics

KW - Ecdysone/biosynthesis

KW - Gene Expression Regulation, Developmental

KW - Genes, Insect

KW - Imaginal Discs/growth & development

KW - Intercellular Signaling Peptides and Proteins/genetics

KW - JNK Mitogen-Activated Protein Kinases/metabolism

KW - Larva/genetics

KW - MAP Kinase Signaling System

KW - Metamorphosis, Biological

KW - RNA Interference

KW - Sequence Deletion

KW - Time Factors

KW - Wings, Animal/growth & development

U2 - 10.1126/science.1216689

DO - 10.1126/science.1216689

M3 - Journal article

C2 - 22556251

VL - 336

SP - 582

EP - 585

JO - Science

JF - Science

SN - 0036-8075

IS - 6081

ER -

ID: 212683105