Seasonal light hours modulate peripheral clocks and energy metabolism in mice
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Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h light:12 h dark photoperiod corresponding to the light duration at the equator. We hypothesized that altering the seasonal photoperiod affects both the rhythmicity of peripheral tissue clocks and energy homeostasis. Mice were housed at photoperiods representing either light hours in summer, winter, or the equinox. Mice housed at a winter photoperiod exhibited an increase in the amplitude of rhythmic lipid metabolism and a modest reduction in fat mass and liver triglyceride content. Comparing melatonin-proficient and -deficient mice, the effect of seasonal light on energy metabolism was largely driven by differences in the rhythmicity of food intake and not melatonin. Together, these data indicate that seasonal light impacts energy metabolism by modulating the timing of eating.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Cell Metabolism |
| Vol/bind | 35 |
| Udgave nummer | 10 |
| Sider (fra-til) | 1722-1735.e5 |
| Antal sider | 20 |
| ISSN | 1550-4131 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) is an independent research center at the University of Copenhagen, partially funded by an unrestricted donation from the Novo Nordisk Foundation ( NNF18CC0034900 ). The authors would like to thank the staff of the Department of Experimental Medicine, the University of Copenhagen for assistance with animal care. We acknowledge the Rodent Metabolic Phenotyping Platform (RMPP) and the Single-Cell Omics Platform (SCOP) at CBMR for their technical and computational expertise and support. L.S. and this project were supported by a research grant from the Danish Diabetes Academy , which is funded by the Novo Nordisk Foundation ( NNF17SA0031406 ). This work was partially funded by a Novo Nordisk Foundation Challenge grant ( NNF14OC0011493 ). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Figure schematics were created with BioRender.com .
Funding Information:
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) is an independent research center at the University of Copenhagen, partially funded by an unrestricted donation from the Novo Nordisk Foundation (NNF18CC0034900). The authors would like to thank the staff of the Department of Experimental Medicine, the University of Copenhagen for assistance with animal care. We acknowledge the Rodent Metabolic Phenotyping Platform (RMPP) and the Single-Cell Omics Platform (SCOP) at CBMR for their technical and computational expertise and support. L.S. and this project were supported by a research grant from the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation (NNF17SA0031406). This work was partially funded by a Novo Nordisk Foundation Challenge grant (NNF14OC0011493). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Figure schematics were created with BioRender.com. Conceptualization, L.S. R.B. and J.R.Z.; investigation, L.S. J.I. A.M.E. A.L.B. E.D. and A.N.H.; formal analysis, L.S. L.S.L. and M.D.; data curation, L.S. L.S.L. and M.D.; funding acquisition, L.S. R.B. and J.R.Z.; methodology, L.S. A.M.E. and A.L.B.; supervision, J.T.T. R.B. and J.R.Z.; visualization, L.S.; writing – original draft, L.S.; writing – review and editing, L.S. A.M.E. M.D. J.T.T. R.B. and J.R.Z. J.R.Z. is an Advisory Board member for Cell and Cell Metabolism. We support inclusive, diverse, and equitable conduct of research.
Publisher Copyright:
© 2023 The Authors
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