Sars-cov-2 in saliva, oropharyngeal and nasopharyngeal specimens
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- SARS-CoV-2 in saliva, oropharyngeal and nasopharyngeal specimens
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INTRODUCTION: The reference test to evaluate patients with suspected respiratory virus infection is a real-time reverse transcription-polymerase chain reaction (RT-PCR) from a nasopharyngeal swab (NPS). However, other specimen collection methods such as an oropharyngeal swab (OPS) or saliva specimen are also used for SARS-CoV-2 testing during the ongoing COVID-19 pandemic. However, it remains unclear if rates of SARS-CoV-2 detection differ between sampling methods. This study will compare the rates of SARS-CoV-2 detection by saliva, OPS, and NPS sampling in a public setting. METHODS: Individuals referred for outpatient SARS-CoV-2 testing will be invited to participate in a prospective clinical study. They will have saliva, OPS and NPS specimens collected that will be analysed separately for SARS-CoV-2 RNA by RT-PCR. The rate of SARS-CoV-2 detection in saliva, OPS and NPS will be compared using a logistic regression mixed-effect model analysis. A sample of 19,110 participants is required at an expected 1.5% test-positive rate in order to detect a 25.6% difference. The total sample size will be adjusted as the test-positive rate changes. CONCLUSIONS: This study will provide evidence for the optimal site of specimen collection to detect SARS-CoV-2. The results may help guide the health authorities.
Originalsprog | Engelsk |
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Artikelnummer | A01210087 |
Tidsskrift | Danish Medical Journal |
Vol/bind | 68 |
Udgave nummer | 5 |
ISSN | 1603-9629 |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
FUNDING: This is an investigator-initiated trial based on an unrestricted grant from the Novo Nordisk Foundation and the Aage og Johanne Louis-Hansens Fond. The foundations have had no say in the decisions on study design or reporting.
Publisher Copyright:
© 2021, Almindelige Danske Laegeforening. All rights reserved.
Links
- https://ugeskriftet.dk/dmj/sars-cov-2-saliva-oropharyngeal-and-nasopharyngeal-specimens
Forlagets udgivne version
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