TY - JOUR

T1 - S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders

AU - Ottesen, Ninja Meinhard

AU - Meluken, Iselin

AU - Frikke-Schmidt, Ruth

AU - Plomgaard, Peter

AU - Scheike, Thomas

AU - Kessing, Lars Vedel

AU - Miskowiak, Kamilla

AU - Vinberg, Maj

PY - 2020

Y1 - 2020

N2 - Background: The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both bio-markers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors-or trait markers for affective disorders. Method: We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk). Results: No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance. Limitations: The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high-and low-risk groups. Conclusion: The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.

AB - Background: The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both bio-markers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors-or trait markers for affective disorders. Method: We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk). Results: No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance. Limitations: The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high-and low-risk groups. Conclusion: The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.

KW - Affective disorder

KW - Monozygotic twins

KW - High-risk-study

KW - S100B

KW - BDNF

KW - BIPOLAR DISORDER

KW - COGNITIVE DYSFUNCTION

KW - MOOD DISORDERS

KW - GLIAL PATHOLOGY

KW - DEPRESSION

KW - PERFORMANCE

KW - IMPAIRMENT

KW - VALIDATION

KW - SINGLETONS

U2 - 10.1016/j.jad.2020.05.015

DO - 10.1016/j.jad.2020.05.015

M3 - Journal article

C2 - 32664008

VL - 274

SP - 726

EP - 732

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -