Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission
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Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission. / Schousboe, A; Sarup, A; Bak, L K; Waagepetersen, H S; Larsson, O M.
I: Neurochemistry International, Bind 45, Nr. 4, 09.2004, s. 521-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission
AU - Schousboe, A
AU - Sarup, A
AU - Bak, L K
AU - Waagepetersen, H S
AU - Larsson, O M
N1 - Copyright 2003 Elsevier Ltd.
PY - 2004/9
Y1 - 2004/9
N2 - The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes. Thus, glutamate transport in astrocytes is mandatory to maintain extrasynaptic glutamate levels sufficiently low to prevent excitotoxic neuronal damage. In GABA synapses hyperactivity of astroglial GABA uptake may lead to diminished GABAergic inhibitory activity resulting in seizures. As a consequence of this the expression and functional activity of astrocytic glutamate and GABA transport is regulated in a number of ways at transcriptional, translational and post-translational levels. This opens for a number of therapeutic strategies by which the efficacy of excitatory and inhibitory neurotransmission may be manipulated.
AB - The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes. Thus, glutamate transport in astrocytes is mandatory to maintain extrasynaptic glutamate levels sufficiently low to prevent excitotoxic neuronal damage. In GABA synapses hyperactivity of astroglial GABA uptake may lead to diminished GABAergic inhibitory activity resulting in seizures. As a consequence of this the expression and functional activity of astrocytic glutamate and GABA transport is regulated in a number of ways at transcriptional, translational and post-translational levels. This opens for a number of therapeutic strategies by which the efficacy of excitatory and inhibitory neurotransmission may be manipulated.
KW - Amino Acid Transport System X-AG
KW - Animals
KW - Astrocytes
KW - Carrier Proteins
KW - GABA Plasma Membrane Transport Proteins
KW - Glutamates
KW - Humans
KW - Membrane Proteins
KW - Membrane Transport Proteins
KW - Synaptic Transmission
KW - gamma-Aminobutyric Acid
U2 - 10.1016/j.neuint.2003.11.001
DO - 10.1016/j.neuint.2003.11.001
M3 - Journal article
C2 - 15186918
VL - 45
SP - 521
EP - 527
JO - Neurochemistry International
JF - Neurochemistry International
SN - 0197-0186
IS - 4
ER -
ID: 152061203