RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1

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Standard

RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. / Nguyen, Thanh Hung; Ralbovska, Adela; Kugler, Jan Michael.

I: G3: Genes, Genomes, Genetics, Bind 10, Nr. 4, 2020, s. 1319-1325.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nguyen, TH, Ralbovska, A & Kugler, JM 2020, 'RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1', G3: Genes, Genomes, Genetics, bind 10, nr. 4, s. 1319-1325. https://doi.org/10.1534/g3.120.401038

APA

Nguyen, T. H., Ralbovska, A., & Kugler, J. M. (2020). RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. G3: Genes, Genomes, Genetics, 10(4), 1319-1325. https://doi.org/10.1534/g3.120.401038

Vancouver

Nguyen TH, Ralbovska A, Kugler JM. RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. G3: Genes, Genomes, Genetics. 2020;10(4):1319-1325. https://doi.org/10.1534/g3.120.401038

Author

Nguyen, Thanh Hung ; Ralbovska, Adela ; Kugler, Jan Michael. / RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. I: G3: Genes, Genomes, Genetics. 2020 ; Bind 10, Nr. 4. s. 1319-1325.

Bibtex

@article{b44b0d9929884d1fafdaac31d0e13abc,
title = "RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1",
abstract = "The Hippo pathway regulates growth and apoptosis. We identify RhoBTB proteins as novel regulators of Hippo signaling. RhoBTB depletion in the Drosophila wing disc epithelium cooperated with Yki to drive hyperplasia into neoplasia. Depletion of RhoBTB2 caused elevated YAP activity in human cells. RhoBTB2 deficiency resulted in increased colony formation in assays for anchorage-independent growth. We provide evidence that RhoBTBs acts on Hippo signaling through regulation of the kinase LKB1. LKB1 protein levels were reduced upon RhoBTB2 depletion, which correlated with increased LKB1 ubiquitination. Restoring LKB1 levels rescued loss of RhoBTB in Drosophila Our results suggest that RhoBTB-dependent LKB1 regulation may contribute to its tumor-suppressive function.",
keywords = "Hippo pathway, LKB1 (STK11), RhoBTB, ubiquitination",
author = "Nguyen, {Thanh Hung} and Adela Ralbovska and Kugler, {Jan Michael}",
year = "2020",
doi = "10.1534/g3.120.401038",
language = "English",
volume = "10",
pages = "1319--1325",
journal = "G3: Genes, Genomes, Genetics (Bethesda)",
issn = "2160-1836",
publisher = "Genetics Society of America",
number = "4",

}

RIS

TY - JOUR

T1 - RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1

AU - Nguyen, Thanh Hung

AU - Ralbovska, Adela

AU - Kugler, Jan Michael

PY - 2020

Y1 - 2020

N2 - The Hippo pathway regulates growth and apoptosis. We identify RhoBTB proteins as novel regulators of Hippo signaling. RhoBTB depletion in the Drosophila wing disc epithelium cooperated with Yki to drive hyperplasia into neoplasia. Depletion of RhoBTB2 caused elevated YAP activity in human cells. RhoBTB2 deficiency resulted in increased colony formation in assays for anchorage-independent growth. We provide evidence that RhoBTBs acts on Hippo signaling through regulation of the kinase LKB1. LKB1 protein levels were reduced upon RhoBTB2 depletion, which correlated with increased LKB1 ubiquitination. Restoring LKB1 levels rescued loss of RhoBTB in Drosophila Our results suggest that RhoBTB-dependent LKB1 regulation may contribute to its tumor-suppressive function.

AB - The Hippo pathway regulates growth and apoptosis. We identify RhoBTB proteins as novel regulators of Hippo signaling. RhoBTB depletion in the Drosophila wing disc epithelium cooperated with Yki to drive hyperplasia into neoplasia. Depletion of RhoBTB2 caused elevated YAP activity in human cells. RhoBTB2 deficiency resulted in increased colony formation in assays for anchorage-independent growth. We provide evidence that RhoBTBs acts on Hippo signaling through regulation of the kinase LKB1. LKB1 protein levels were reduced upon RhoBTB2 depletion, which correlated with increased LKB1 ubiquitination. Restoring LKB1 levels rescued loss of RhoBTB in Drosophila Our results suggest that RhoBTB-dependent LKB1 regulation may contribute to its tumor-suppressive function.

KW - Hippo pathway

KW - LKB1 (STK11)

KW - RhoBTB

KW - ubiquitination

U2 - 10.1534/g3.120.401038

DO - 10.1534/g3.120.401038

M3 - Journal article

C2 - 32111652

VL - 10

SP - 1319

EP - 1325

JO - G3: Genes, Genomes, Genetics (Bethesda)

JF - G3: Genes, Genomes, Genetics (Bethesda)

SN - 2160-1836

IS - 4

ER -

ID: 240143130