Retrotransposons and non-protein coding RNAs
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Retrotransposons and non-protein coding RNAs. / Mourier, Tobias; Willerslev, Eske.
I: Briefings in Functional Genomics and Proteomics, 2009.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Retrotransposons and non-protein coding RNAs
AU - Mourier, Tobias
AU - Willerslev, Eske
PY - 2009
Y1 - 2009
N2 - Retrotransposons constitute a significant fraction of mammalian genomes. Considering the finding of widespread transcriptional activity across entire genomes, it is not surprising that retrotransposons contribute to the collective RNA pool. However, the transcriptional output from retrotransposons does not merely represent spurious transcription. We review examples of functional RNAs transcribed from retrotransposons, and address the collection of non-protein coding RNAs derived from transposable element sequences, including numerous human microRNAs and the neuronal BC RNAs. Finally, we review the emerging understanding of how retrotransposons themselves are regulated by small RNAs.
AB - Retrotransposons constitute a significant fraction of mammalian genomes. Considering the finding of widespread transcriptional activity across entire genomes, it is not surprising that retrotransposons contribute to the collective RNA pool. However, the transcriptional output from retrotransposons does not merely represent spurious transcription. We review examples of functional RNAs transcribed from retrotransposons, and address the collection of non-protein coding RNAs derived from transposable element sequences, including numerous human microRNAs and the neuronal BC RNAs. Finally, we review the emerging understanding of how retrotransposons themselves are regulated by small RNAs.
U2 - 10.1093/bfgp/elp036
DO - 10.1093/bfgp/elp036
M3 - Journal article
C2 - 19729447
JO - Briefings in Functional Genomics
JF - Briefings in Functional Genomics
SN - 2041-2649
ER -
ID: 14466939