Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Physiologically, the programmed death 1 (PD-1) pathway is involved in limiting the killing of bystander cells during an infection and controlling autoimmunity. However, cancers exploit this system to avoid immune killing, and PD-1 ligand 1 and 2 (PD-L1 and PD-L2) expression on tumor cells, as well as PD-1 expression on tumor-infiltrating lymphocytes, have shown to be negative prognostic factors. Promising clinical results have been obtained by PD-1 pathway blockade in a range of cancers while still maintaining a manageable toxicity profile, and two anti-PD-1 antibodies are now approved by the US Food and Drug Administration (FDA) for the treatment of metastatic melanoma. As already shown with nivolumab and ipilimumab, the combination of PD-1 pathway blockade with other anticancer agents holds promise in the form of additive synergistic anticancer effects.
Originalsprog | Engelsk |
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Tidsskrift | Drug Discovery Today |
Vol/bind | 20 |
Udgave nummer | 9 |
Sider (fra-til) | 1127-34 |
Antal sider | 8 |
ISSN | 1359-6446 |
DOI | |
Status | Udgivet - sep. 2015 |
ID: 162339780