Remodelling of the extracellular matrix: Implications for cancer

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

Remodelling of the extracellular matrix : Implications for cancer. / Cox, Thomas R.; Erler, Janine T.

Cell and Molecular Biology of Breast Cancer. Humana Press, 2013. s. 65-90.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

Cox, TR & Erler, JT 2013, Remodelling of the extracellular matrix: Implications for cancer. i Cell and Molecular Biology of Breast Cancer. Humana Press, s. 65-90. https://doi.org/10.1007/978-1-62703-634-4_4

APA

Cox, T. R., & Erler, J. T. (2013). Remodelling of the extracellular matrix: Implications for cancer. I Cell and Molecular Biology of Breast Cancer (s. 65-90). Humana Press. https://doi.org/10.1007/978-1-62703-634-4_4

Vancouver

Cox TR, Erler JT. Remodelling of the extracellular matrix: Implications for cancer. I Cell and Molecular Biology of Breast Cancer. Humana Press. 2013. s. 65-90 https://doi.org/10.1007/978-1-62703-634-4_4

Author

Cox, Thomas R. ; Erler, Janine T. / Remodelling of the extracellular matrix : Implications for cancer. Cell and Molecular Biology of Breast Cancer. Humana Press, 2013. s. 65-90

Bibtex

@inbook{8b832945aa914c9abc3bd45e63ff8c34,
title = "Remodelling of the extracellular matrix: Implications for cancer",
abstract = "Remodelling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. The tight control of biochemical and biomechanical properties of the ECM and the ongoing remodelling of the ECM is critical in maintaining correct organ function. When this remodelling becomes excessive or uncontrolled, life-threatening pathological conditions such as cancer can result. In this chapter, we focus on the importance and complexity of cell-ECM interactions in determining correct cell behaviour under normal conditions and what happens when it all goes wrong in situations of cancer. We discuss the pathogenesis of breast cancer initiation, progression and metastatic dissemination in the context of the ECM and illustrate how dynamic ECM remodelling contributes to all of these stages. We discuss how improving our understanding of ECM remodelling in all stages of carcinogenesis is crucial for uncovering novel therapeutic targets and treatment strategies for a disease which currently presents challenging obstacles with respect to clinical treatment.",
author = "Cox, {Thomas R.} and Erler, {Janine T.}",
year = "2013",
month = jun,
day = "1",
doi = "10.1007/978-1-62703-634-4_4",
language = "English",
isbn = "1627036334",
pages = "65--90",
booktitle = "Cell and Molecular Biology of Breast Cancer",
publisher = "Humana Press",
address = "United States",

}

RIS

TY - CHAP

T1 - Remodelling of the extracellular matrix

T2 - Implications for cancer

AU - Cox, Thomas R.

AU - Erler, Janine T.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Remodelling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. The tight control of biochemical and biomechanical properties of the ECM and the ongoing remodelling of the ECM is critical in maintaining correct organ function. When this remodelling becomes excessive or uncontrolled, life-threatening pathological conditions such as cancer can result. In this chapter, we focus on the importance and complexity of cell-ECM interactions in determining correct cell behaviour under normal conditions and what happens when it all goes wrong in situations of cancer. We discuss the pathogenesis of breast cancer initiation, progression and metastatic dissemination in the context of the ECM and illustrate how dynamic ECM remodelling contributes to all of these stages. We discuss how improving our understanding of ECM remodelling in all stages of carcinogenesis is crucial for uncovering novel therapeutic targets and treatment strategies for a disease which currently presents challenging obstacles with respect to clinical treatment.

AB - Remodelling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. The tight control of biochemical and biomechanical properties of the ECM and the ongoing remodelling of the ECM is critical in maintaining correct organ function. When this remodelling becomes excessive or uncontrolled, life-threatening pathological conditions such as cancer can result. In this chapter, we focus on the importance and complexity of cell-ECM interactions in determining correct cell behaviour under normal conditions and what happens when it all goes wrong in situations of cancer. We discuss the pathogenesis of breast cancer initiation, progression and metastatic dissemination in the context of the ECM and illustrate how dynamic ECM remodelling contributes to all of these stages. We discuss how improving our understanding of ECM remodelling in all stages of carcinogenesis is crucial for uncovering novel therapeutic targets and treatment strategies for a disease which currently presents challenging obstacles with respect to clinical treatment.

UR - http://www.scopus.com/inward/record.url?scp=84929879037&partnerID=8YFLogxK

U2 - 10.1007/978-1-62703-634-4_4

DO - 10.1007/978-1-62703-634-4_4

M3 - Book chapter

AN - SCOPUS:84929879037

SN - 1627036334

SN - 9781627036337

SP - 65

EP - 90

BT - Cell and Molecular Biology of Breast Cancer

PB - Humana Press

ER -

ID: 234659268