P-Type ATPases
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P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably simple with only a single catalytic subunit and carry out large domain motions during transport. The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Phylogenetically, P-type ATPases are divided into five subfamilies, P1P5. These subfamilies differ with respect to transported ligands and the way they are regulated.
Originalsprog | Engelsk |
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Tidsskrift | Annual Review of Biophysics |
Vol/bind | 40 |
Udgave nummer | 1 |
Sider (fra-til) | 243-266 |
Antal sider | 24 |
ISSN | 1936-122X |
DOI | |
Status | Udgivet - 2011 |
ID: 245000720